Phenotypes associated with this allele

• Allele Symbol: Olfm2^tm1.1Sit
• Allele Name: targeted mutation 1.1, Stanilsav I Tomarev
• Allele ID: MGI:5706836
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Olfm2^tm1.1Sit/Olfm2^tm1.1Sit	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:5707684

Genotype
MGI:5707684

hm1

• Allelic Composition: Olfm2^tm1.1Sit/Olfm2^tm1.1Sit
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:217902 )

N • normal life span

N • no postnatal lethality

growth/size/body

growth/size/body region phenotype ( J:217902 )

N • normal body weight and no other gross phenotypic defects

vision/eye

vision/eye phenotype ( J:217902 )

N • normal intraocular pressure

N • ERG b-wave amplitude and peak time responses are normal

abnormal optic nerve morphology ( J:217902 )

• myelin sheath appears to be less compact

• 8% reduction in axons of the optic nerve although this does not reach significance

abnormal visual evoked potential ( J:217902 )

• significantly decreased amplitude of the first negative wave

behavior/neurological

abnormal anxiety-related response ( J:217902 )

• enter open arms of an elevated maze more frequently and spend more time in open arms

abnormal motor capabilities/coordination/movement ( J:217902 )

impaired coordination ( J:217902 )

• reduced coordination on a rotarod test

decreased vertical activity ( J:217902 )

• reduced rearing

decreased locomotor activity ( J:217902 )

• reduced distance travelled in an open field test

• prefer lit areas of an open field

nervous system

abnormal optic nerve morphology ( J:217902 )

• myelin sheath appears to be less compact

• 8% reduction in axons of the optic nerve although this does not reach significance