All Phenotypes Dusp5<tm1.1Skey> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dusp5^tm1.1Skey
targeted mutation 1.1, Stephen M Keyse
MGI:5706846

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp5^tm1.1Skey/Dusp5^tm1.1Skey	involves: C57BL/6 * C57BL/6NTac	MGI:5906770
ht2	Dusp5^tm1.1Skey/Dusp5⁺	involves: C57BL/6 * C57BL/6NTac	MGI:5906773
cx3	Dusp5^tm1.1Skey/Dusp5^tm1.1Skey Serpinb2^tm1Dgi/Serpinb2^tm1Dgi	involves: 129S1/Sv * C57BL/6 * C57BL/6NTac	MGI:5906772

Allelic Composition	Dusp5^tm1.1Skey/Dusp5^tm1.1Skey
Genetic Background	involves: C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dusp5^tm1.1Skey mutation (0 available); any Dusp5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:216939 )

• DMBA/TPA-treated mice reach 100% skin papilloma incidence sooner than in wild-type mice with more tumors per mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:216939 )

• DMBA/TPA-treated mice reach 100% skin papilloma incidence sooner than in wild-type mice with more tumors per mice

Allelic Composition	Dusp5^tm1.1Skey/Dusp5⁺
Genetic Background	involves: C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dusp5^tm1.1Skey mutation (0 available); any Dusp5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:216939 )

• DMBA/TPA-treated mice reach 100% skin papilloma incidence sooner than in wild-type mice with more tumors per mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:216939 )

• DMBA/TPA-treated mice reach 100% skin papilloma incidence sooner than in wild-type mice with more tumors per mice

Allelic Composition	Dusp5^tm1.1Skey/Dusp5^tm1.1Skey Serpinb2^tm1Dgi/Serpinb2^tm1Dgi
Genetic Background	involves: 129S1/Sv * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dusp5^tm1.1Skey mutation (0 available); any Dusp5 mutation (16 available)
Serpinb2^tm1Dgi mutation (1 available); any Serpinb2 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:216939 )

N	• mice exhibit normal susceptibility to DMBA/TPA-induced skin papilloma

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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