Phenotypes associated with this allele

• Allele Symbol: Tg(Alb-MYLIP*)1Pton
• Allele Name: transgene insertion 1, Peter Tontonoz
• Allele ID: MGI:5706928
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Alb-MYLIP*)1Pton/?	involves: C57BL/6J	MGI:5707295

Genotype
MGI:5707295

tg1

• Allelic Composition: Tg(Alb-MYLIP*)1Pton/?
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:228420 )

• mice develop atherosclerotic lesions after 20 weeks on western diet

• area of lesions increases after 30 weeks on western diet

• males develop more lesions than females

• in aortic root some lesions exhibit an acellular core and collagen deposition

• lesion phenotype is less severe than in homozygous Ldlr^tm1Her mice

increased susceptibility to atherosclerosis ( J:228420 )

growth/size/body

abnormal body fat mass ( J:228420 )

♂ • slight reduction in hepatic fat mass after 20 weeks on western diet

homeostasis/metabolism

increased circulating cholesterol level ( J:228420 )

increased circulating LDL cholesterol level ( J:228420 )

• on western diet

decreased circulating triglyceride level ( J:228420 )

♂ • decreased triglyceride levels after 20 weeks on chow diet

increased circulating triglyceride level ( J:228420 )

♂ • increased triglyceride levels after 20 and 30 weeks on western diet

adipose tissue

abnormal body fat mass ( J:228420 )

♂ • slight reduction in hepatic fat mass after 20 weeks on western diet