Phenotypes associated with this allele

• Allele Symbol: Phf24^{tm1.2(HBEGF)Azmo}
• Allele Name: targeted mutation 1.2, Aziz Moqrich
• Allele ID: MGI:5706936
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phf24^tm1.2(HBEGF)Azmo/Phf24^tm1.2(HBEGF)Azmo	involves: 129 * BALB/cJ * C57BL/6	MGI:5707781

Genotype
MGI:5707781

hm1

• Allelic Composition: Phf24^{tm1.2(HBEGF)Azmo}/Phf24^{tm1.2(HBEGF)Azmo}
• Genetic Background: involves: 129 * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:218052 )

N • neuronal counts in dorsal root ganglia are normal

behavior/neurological

behavior/neurological phenotype ( J:218052 )

N • thermotaxis gradient tests, hot and cold plate tests and Hargreaves tests all normal

abnormal chemical nociception ( J:218052 )

• in formalin tests, first response is typical

• second response is earlier but actual time spent in response behaviors is similar to controls

abnormal mechanical nociception ( J:218052 )

• acute mechanical pain responses are normal

• in a carageenan model, hypersensitivity developed typically but persisted longer

• chronic constriction injury models of pain also show a longer duration for pain responses

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:218052 )

• no analgesic effect of interthecal injection of baclofen in a spared nerve injury model of pain

• inhibitory effect of baclophen on HVA Ca channels is significantly reduced

• the presynaptic inhibition of invoked responses by baclofen is impaired (lowered paired pulse ratio)