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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Helz2tm1Tesa
targeted mutation 1, Tetsurou Satoh
MGI:5707023
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Helz2tm1Tesa/Helz2tm1Tesa B6.Cg-Helz2tm1Tesa MGI:5707501
cx2
Helz2tm1Tesa/Helz2tm1Tesa
Leprdb/Leprdb
involves: C57BL/6 * C57BLKS/J MGI:5707502


Genotype
MGI:5707501
hm1
Allelic
Composition
Helz2tm1Tesa/Helz2tm1Tesa
Genetic
Background
B6.Cg-Helz2tm1Tesa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Helz2tm1Tesa mutation (0 available); any Helz2 mutation (140 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• normal food intake on a normal diet
• normal locomotor activity on a normal diet

growth/size/body
N
• body weight gain is normal on a normal diet
• weight gain is less than for controls on a high fat diet

homeostasis/metabolism
N
• normal fasting blood glucose on a normal diet
• insulin levels are normal on a normal diet
• leptin levels normal on a normal diet
• normal adiponectin levels on a normal diet
• sustained hyperleptinemia on a high fat diet
• relative to controls on a high fat diet
• relative to controls on a high fat diet
• less fat deposition than controls on a high fat diet
• triglyceride levels are reduced in the liver on a high fat diet

liver/biliary system
• triglyceride levels are reduced in the liver on a high fat diet
• liver enlargement is reduced relative to controls on a high fat diet
• ameliorated relative to controls on a high fat diet




Genotype
MGI:5707502
cx2
Allelic
Composition
Helz2tm1Tesa/Helz2tm1Tesa
Leprdb/Leprdb
Genetic
Background
involves: C57BL/6 * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Helz2tm1Tesa mutation (0 available); any Helz2 mutation (140 available)
Leprdb mutation (17 available); any Lepr mutation (122 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• mice have no protection against obesity on a high fat diet





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory