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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj
targeted mutation 1, Jae-Wook Jeong
MGI:5707028
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5780554
cn2
 		Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5780553


Genotype
MGI:5780554
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj mutation (1 available); any Gt(ROSA)26Sor mutation (992 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:218222 )
• mice exhibit significantly increased survival time relative to mice that are homozygous for Ptentm1Hwu and heterozygous for Pgrtm2(cre)Lyd, with >50% of mice still viable at 64 weeks of age
• mice do not die due to the development of endometrial cancer

reproductive system
endometrium hyperplasia ( J:218222 )
• mice exhibit endometrial hyperplasia at 2 months but not at 3 months of age
• however, endometrial adenocarcinoma with invasion into the myometrium is not observed due to inhibition of ERK1/2 phosphorylation
increased uterus weight ( J:218222 )
• at 3 months of age, mice show a significantly reduced increase in uterine/body weight ratio relative to mice that are homozygous for Ptentm1Hwu and heterozygous for Pgrtm2(cre)Lyd
abnormal uterus physiology ( J:218222 )
• at 2 months of age, mice show a significantly reduced uterine epithelial cell proliferation relative to mice that are homozygous for Ptentm1Hwu and heterozygous for Pgrtm2(cre)Lyd

neoplasm
increased papilloma incidence ( J:218222 )
• mice develop vaginal papillomas




Genotype
MGI:5780553
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj mutation (1 available); any Gt(ROSA)26Sor mutation (992 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:218222 )
• mice exhibit normal survival with no differences in uterine/body weight ratio or uterine morphology at 2-3 months of age relative to controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory