About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj
targeted mutation 1, Jae-Wook Jeong
MGI:5707028
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5780554
cn2
 		Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5780553


Genotype
MGI:5780554
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:218222 )
• mice exhibit significantly increased survival time relative to mice that are homozygous for Ptentm1Hwu and heterozygous for Pgrtm2(cre)Lyd, with >50% of mice still viable at 64 weeks of age
• mice do not die due to the development of endometrial cancer

reproductive system
endometrium hyperplasia ( J:218222 )
• mice exhibit endometrial hyperplasia at 2 months but not at 3 months of age
• however, endometrial adenocarcinoma with invasion into the myometrium is not observed due to inhibition of ERK1/2 phosphorylation
increased uterus weight ( J:218222 )
• at 3 months of age, mice show a significantly reduced increase in uterine/body weight ratio relative to mice that are homozygous for Ptentm1Hwu and heterozygous for Pgrtm2(cre)Lyd
abnormal uterus physiology ( J:218222 )
• at 2 months of age, mice show a significantly reduced uterine epithelial cell proliferation relative to mice that are homozygous for Ptentm1Hwu and heterozygous for Pgrtm2(cre)Lyd

neoplasm
increased papilloma incidence ( J:218222 )
• mice develop vaginal papillomas




Genotype
MGI:5780553
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:218222 )
• mice exhibit normal survival with no differences in uterine/body weight ratio or uterine morphology at 2-3 months of age relative to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory