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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lonp1tm1Otin
targeted mutation 1, Carlos Lopez-Otin
MGI:5707160
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lonp1tm1Otin/Lonp1tm1Otin Not Specified MGI:5707192
ht2
Lonp1tm1Otin/Lonp1+ Not Specified MGI:5707193


Genotype
MGI:5707192
hm1
Allelic
Composition
Lonp1tm1Otin/Lonp1tm1Otin
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lonp1tm1Otin mutation (0 available); any Lonp1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• though present in Mendelian ratios at E3.5, only 1 mouse is present at E8.5 and no mice are present at E9.5

embryo
• at E7.5 and E8.5
• however, mice are normal size at E5.5 and E6.5
• at E7.5 and E8.5
• however, mice are normal size at E5.5 and E6.5

cellular

growth/size/body
• at E7.5 and E8.5
• however, mice are normal size at E5.5 and E6.5
• at E7.5 and E8.5
• however, mice are normal size at E5.5 and E6.5




Genotype
MGI:5707193
ht2
Allelic
Composition
Lonp1tm1Otin/Lonp1+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lonp1tm1Otin mutation (0 available); any Lonp1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice treated with azoxymethane (AOM) and dextrane sulfate exhibit fewer incidences and numbers of colorectal tumors compared with wild-type mice
• mice treated with a 7,12-dimethylbenzanthracene and tetradecanoylphorbol acetate (DMBA/TPA) develop fewer and smaller papillomas compared with wild-type mice

homeostasis/metabolism
• mice treated with azoxymethane (AOM) and dextrane sulfate exhibit fewer incidences and numbers of colorectal tumors compared with wild-type mice
• mice treated with a 7,12-dimethylbenzanthracene and tetradecanoylphorbol acetate (DMBA/TPA) develop fewer and smaller papillomas compared with wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory