About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lonp1tm1Otin
targeted mutation 1, Carlos Lopez-Otin
MGI:5707160
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lonp1tm1Otin/Lonp1tm1Otin Not Specified MGI:5707192
ht2
Lonp1tm1Otin/Lonp1+ Not Specified MGI:5707193


Genotype
MGI:5707192
hm1
Allelic
Composition
Lonp1tm1Otin/Lonp1tm1Otin
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lonp1tm1Otin mutation (0 available); any Lonp1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• though present in Mendelian ratios at E3.5, only 1 mouse is present at E8.5 and no mice are present at E9.5

embryo
• at E7.5 and E8.5
• however, mice are normal size at E5.5 and E6.5
• at E7.5 and E8.5
• however, mice are normal size at E5.5 and E6.5

cellular

growth/size/body
• at E7.5 and E8.5
• however, mice are normal size at E5.5 and E6.5
• at E7.5 and E8.5
• however, mice are normal size at E5.5 and E6.5




Genotype
MGI:5707193
ht2
Allelic
Composition
Lonp1tm1Otin/Lonp1+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lonp1tm1Otin mutation (0 available); any Lonp1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice treated with azoxymethane (AOM) and dextrane sulfate exhibit fewer incidences and numbers of colorectal tumors compared with wild-type mice
• mice treated with a 7,12-dimethylbenzanthracene and tetradecanoylphorbol acetate (DMBA/TPA) develop fewer and smaller papillomas compared with wild-type mice

homeostasis/metabolism
• mice treated with azoxymethane (AOM) and dextrane sulfate exhibit fewer incidences and numbers of colorectal tumors compared with wild-type mice
• mice treated with a 7,12-dimethylbenzanthracene and tetradecanoylphorbol acetate (DMBA/TPA) develop fewer and smaller papillomas compared with wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory