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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Sftpc-Grem1)105Mmyl
transgene insertion 105, Marjukka Myllarniemi
MGI:5707177
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm2(cre/ERT2)Brn/0
Tg(Sftpc-Grem1)105Mmyl/0
involves: 129P2/OlaHsd * C57BL/6N MGI:5707181
tg2
Tg(Sftpc-Grem1)105Mmyl/0 C57BL/6N-Tg(Sftpc-Grem1)105Mmyl MGI:5707179


Genotype
MGI:5707181
cn1
Allelic
Composition
Gt(ROSA)26Sortm2(cre/ERT2)Brn/0
Tg(Sftpc-Grem1)105Mmyl/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Sftpc-Grem1)105Mmyl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following exposure to silica, the lung tissue of these mice exhibits significantly less inflammatory cell infiltration than that of wild-type mice.

respiratory system
• following exposure to silica, the lung tissue of these mice exhibits significantly less inflammatory cell infiltration than that of wild-type mice.
• at 6 months of age, these mice may exhibit some alveolar space enlargement
• at 6 months of age, these mice exhibit mild septal thickening
• the lungs of these mice exhibit no histologically apparent alterations in fibrosis following exposure to silica




Genotype
MGI:5707179
tg2
Allelic
Composition
Tg(Sftpc-Grem1)105Mmyl/0
Genetic
Background
C57BL/6N-Tg(Sftpc-Grem1)105Mmyl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Sftpc-Grem1)105Mmyl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory