immune system
• following exposure to silica, the lung tissue of these mice exhibits significantly less inflammatory cell infiltration than that of wild-type mice.
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respiratory system
• following exposure to silica, the lung tissue of these mice exhibits significantly less inflammatory cell infiltration than that of wild-type mice.
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• at 6 months of age, these mice may exhibit some alveolar space enlargement
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• at 6 months of age, these mice exhibit mild septal thickening
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• the lungs of these mice exhibit no histologically apparent alterations in fibrosis following exposure to silica
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