About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Sftpc-Grem1)105Mmyl
transgene insertion 105, Marjukka Myllarniemi
MGI:5707177
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm2(cre/ERT2)Brn/0
Tg(Sftpc-Grem1)105Mmyl/0
involves: 129P2/OlaHsd * C57BL/6N MGI:5707181
tg2
Tg(Sftpc-Grem1)105Mmyl/0 C57BL/6N-Tg(Sftpc-Grem1)105Mmyl MGI:5707179


Genotype
MGI:5707181
cn1
Allelic
Composition
Gt(ROSA)26Sortm2(cre/ERT2)Brn/0
Tg(Sftpc-Grem1)105Mmyl/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Sftpc-Grem1)105Mmyl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following exposure to silica, the lung tissue of these mice exhibits significantly less inflammatory cell infiltration than that of wild-type mice.

respiratory system
• following exposure to silica, the lung tissue of these mice exhibits significantly less inflammatory cell infiltration than that of wild-type mice.
• at 6 months of age, these mice may exhibit some alveolar space enlargement
• at 6 months of age, these mice exhibit mild septal thickening
• the lungs of these mice exhibit no histologically apparent alterations in fibrosis following exposure to silica




Genotype
MGI:5707179
tg2
Allelic
Composition
Tg(Sftpc-Grem1)105Mmyl/0
Genetic
Background
C57BL/6N-Tg(Sftpc-Grem1)105Mmyl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Sftpc-Grem1)105Mmyl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory