Phenotypes associated with this allele

• Allele Symbol: Net1^tm1.2Jafr
• Allele Name: targeted mutation 1.2, Jeffrey A Frost
• Allele ID: MGI:5707255
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Net1^tm1.2Jafr/Net1^tm1.2Jafr	involves: C57BL/6 * SJL	MGI:5707947

Genotype
MGI:5707947

hm1

• Allelic Composition: Net1^tm1.2Jafr/Net1^tm1.2Jafr
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:218290 )

♀ • development is slowed

abnormal branching of the mammary ductal tree ( J:218290 )

♀ • reduced ductal branching at 6 weeks and at 12 weeks

♀ • ductal layer organization worsens with age

♀ • multiple layers form and an intermingling of myoepithelial and luminal epithelial cells occurs

♀ • more collagen deposited around ducts

abnormal mammary gland bud elongation ( J:218290 )

♀ • reduced cell proliferation in terminal end buds at 6 weeks

♀ • cell proliferation continues past 12 weeks when it has ceased in controls

adipose tissue

abnormal mammary fat pad morphology ( J:218290 )

♀ • reduced filling of mammary fat pad with mammary gland ducts compared to controls at 6 weeks

♀ • fat pad filling is identical to controls at 12 weeks

integument

abnormal mammary gland development ( J:218290 )

♀ • development is slowed

abnormal branching of the mammary ductal tree ( J:218290 )

♀ • ductal layer organization worsens with age

♀ • reduced ductal branching at 6 weeks and at 12 weeks

♀ • multiple layers form and an intermingling of myoepithelial and luminal epithelial cells occurs

♀ • more collagen deposited around ducts

abnormal mammary gland bud elongation ( J:218290 )

♀ • reduced cell proliferation in terminal end buds at 6 weeks

♀ • cell proliferation continues past 12 weeks when it has ceased in controls