Phenotypes associated with this allele

• Allele Symbol: Afap1^tm1.2Ycho
• Allele Name: targeted mutation 1.2, Youngjin Cho
• Allele ID: MGI:5707264
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Afap1^tm1.2Ycho/Afap1^tm1.2Ycho	involves: BALB/cJ * C57BL/6J	MGI:5707290

Genotype
MGI:5707290

hm1

• Allelic Composition: Afap1^tm1.2Ycho/Afap1^tm1.2Ycho
• Genetic Background: involves: BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal involution of the mammary gland ( J:221250 )

♀ • precocious involution at early lactation

abnormal mammary gland alveolus morphology ( J:221250 )

♀ • lactating mammary glands exhibit less dense and less full alveoli sparse milk residue in lumens compared with wild-type mice

♀ • however, mammary gland morphology at 4, 8 and 14 weeks and at P16.5 is normal and alveoli exhibit normal number of cells

abnormal lactation ( J:221250 )

♀ • sparse milk residue in lumens

♀ • mice exhibit failed secretory activation

♀ • however, cytoplasmic lipid droplets stain positive for adipose differentiation-related protein

abnormal milk composition ( J:221250 )

♀ • reduced milk lipid synthesis

♀ • however, milk protein synthesis is normal

behavior/neurological

absent gastric milk in neonates ( J:221250 )

• very small or no milk spots

abnormal nursing ( J:221250 )

♀ • dams are unable to foster wild-type pups

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:221250 )

♀ • precocious involution at early lactation

abnormal mammary gland alveolus morphology ( J:221250 )

♀ • lactating mammary glands exhibit less dense and less full alveoli sparse milk residue in lumens compared with wild-type mice

♀ • however, mammary gland morphology at 4, 8 and 14 weeks and at P16.5 is normal and alveoli exhibit normal number of cells

abnormal lactation ( J:221250 )

♀ • sparse milk residue in lumens

♀ • mice exhibit failed secretory activation

♀ • however, cytoplasmic lipid droplets stain positive for adipose differentiation-related protein

abnormal milk composition ( J:221250 )

♀ • reduced milk lipid synthesis

♀ • however, milk protein synthesis is normal

cellular

maternal effect ( J:221250 )

♀ • pups fostered by homozygous mice exhibit reduced weight gain

♀ • however, mice fostered by wild-type dams exhibit normal weight gain