digestive/alimentary system
• some mice develop rectal prolapse after 6 months of age
|
• soft stools
|
endocrine/exocrine glands
|
• males develop an inflamed preputial gland
|
growth/size/body
• adult mice are smaller than controls; weight gain peaks at 9 weeks and plateaus at 21-23 grams
• adults are 43% smaller than wild-type and 33% smaller than heterozygotes
• males are smaller from birth
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integument
• alopecia is more severe than in hemizygous mutant mice
• alopecia appears between 3-8 weeks of age
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muscle
N |
• mice exhibit no overt myopathy
|
reproductive system
|
• males develop an inflamed preputial gland
|
immune system
|
• males develop an inflamed preputial gland
|