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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ankrd1tm1.2Jmda
targeted mutation 1.2, Jeffrey M Davidson
MGI:5707279
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda B6.129S6(Cg)-Ankrd1tm1.2Jmda MGI:5708103
hm2
 		Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda involves: 129S6/SvEvTac * C57BL/6J MGI:5708100
ht3
 		Ankrd1tm1.2Jmda/Ankrd1+ involves: 129S6/SvEvTac * C57BL/6J MGI:5708101


Genotype
MGI:5708103
hm1
Allelic
Composition		 Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic
Background		 B6.129S6(Cg)-Ankrd1tm1.2Jmda
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd1tm1.2Jmda mutation (0 available); any Ankrd1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
abnormal postnatal growth ( J:218253 )
• growth diminishing effect

homeostasis/metabolism
delayed wound healing ( J:218253 )
• retarded until at least 21 days after injury

integument
epidermal necrosis ( J:218253 )
• increased wound skin flap necrosis
• necrosis less severe in heterozygotes
• treatment with adenovirus expressing ANKRD1 can reduce necrosis (in controls as well)




Genotype
MGI:5708100
hm2
Allelic
Composition		 Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd1tm1.2Jmda mutation (0 available); any Ankrd1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:218253 )
N
• normal litter size and Mendelian ratios

homeostasis/metabolism
delayed wound healing ( J:218253 )
• openings contract more slowly
• delay is particularly significant between days 6 and 8 after injury
impaired wound healing ( J:218253 )
• mildly impaired
• thinner granulation tissues and wider wound gap

growth/size/body
growth/size/body region phenotype ( J:218253 )
N
• body weight and organ weights of spleen, liver, kidney, brain, and skeletal muscle all normal

cardiovascular system
abnormal heart ventricles weight ( J:218253 )
• significantly increased in both sexes




Genotype
MGI:5708101
ht3
Allelic
Composition		 Ankrd1tm1.2Jmda/Ankrd1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd1tm1.2Jmda mutation (0 available); any Ankrd1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired wound healing ( J:218253 )
• mildly impaired

cardiovascular system
abnormal heart ventricles weight ( J:218253 )
• females only show a moderate increase




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory