mortality/aging
• between 8 and 16 weeks of age compared with C57BL/6J mice
|
renal/urinary system
• mice exhibit increased urinary excretion of cysteine and dibasic amino acids (arginine, lysine and ornithine) compared with C57BL/6J mice
|
cystinuria
(
J:219017
)
argininuria
(
J:219017
)
ornithinuria
(
J:219017
)
• bilateral renal dilation in mice that die between 8 and 16 weeks of age
|
• focal increased cellularity in kidney cortex interstitium due to inflammatory cell infiltrate, including lymphocytes and macrophages
• however, interstitial fibrosis is not observed
|
• bilateral
• however, mice that survive until 16 weeks are not affected by hydronephrosis
|
homeostasis/metabolism
• in mice that survive until 16 weeks
|
• mice exhibit increased urinary excretion of cysteine and dibasic amino acids (arginine, lysine and ornithine) compared with C57BL/6J mice
|
cystinuria
(
J:219017
)
argininuria
(
J:219017
)
ornithinuria
(
J:219017
)
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
cystinuria | DOID:9266 |
OMIM:220100 |
J:219017 |