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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc3a1m1Crl
mutation 1, Charles River Laboratories
MGI:5707297
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc3a1m1Crl/Slc3a1m1Crl 129S2/SvPasCrl MGI:5707340


Genotype
MGI:5707340
hm1
Allelic
Composition
Slc3a1m1Crl/Slc3a1m1Crl
Genetic
Background
129S2/SvPasCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc3a1m1Crl mutation (0 available); any Slc3a1 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• between 8 and 16 weeks of age compared with C57BL/6J mice

renal/urinary system
• mice exhibit increased urinary excretion of cysteine and dibasic amino acids (arginine, lysine and ornithine) compared with C57BL/6J mice
• bilateral renal dilation in mice that die between 8 and 16 weeks of age
• focal increased cellularity in kidney cortex interstitium due to inflammatory cell infiltrate, including lymphocytes and macrophages
• however, interstitial fibrosis is not observed
• bilateral
• however, mice that survive until 16 weeks are not affected by hydronephrosis

homeostasis/metabolism
• in mice that survive until 16 weeks
• mice exhibit increased urinary excretion of cysteine and dibasic amino acids (arginine, lysine and ornithine) compared with C57BL/6J mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cystinuria DOID:9266 OMIM:220100
J:219017





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory