Phenotypes associated with this allele

• Allele Symbol: Clpx^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5707301
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clpx^tm1.1(KOMP)Vlcg/Clpx^tm1.1(KOMP)Vlcg	B6N(Cg)-Clpx^tm1.1(KOMP)Vlcg/J	MGI:6262162
hm2	Clpx^tm1.1(KOMP)Vlcg/Clpx^tm1.1(KOMP)Vlcg	C57BL/6N-Clpx^tm1.1(KOMP)Vlcg/JMmucd	MGI:7736597

Genotype
MGI:6262162

hm1

• Allelic Composition: Clpx^{tm1.1(KOMP)Vlcg}/Clpx^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Clpx^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 14944A-C8

Data Sources

IMPC Data for Clpx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:7736597

hm2

• Allelic Composition: Clpx^{tm1.1(KOMP)Vlcg}/Clpx^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Clpx^{tm1.1(KOMP)Vlcg}/JMmucd
• Cell Lines: 14944A-C8

Clpx^{tm1.1(KOMP)Vlcg}/Clpx^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E7.5 (17% versus expected 25%, n=29) and arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:290315 , J:279207 )

• no hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5