Phenotypes associated with this allele

• Allele Symbol: Wee1^tm1Cxd
• Allele Name: targeted mutation 1, Chu-Xia Deng
• Allele ID: MGI:5707451
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-cre/Esr1*)5Amc/0 Wee1^tm1Cxd/Wee1^tm1Cxd	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:5707476

Genotype
MGI:5707476

cn1

• Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0; Wee1^tm1Cxd/Wee1^tm1Cxd
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:228492 )

• mouse embryonic fibroblasts treated with tamoxifen exhibit nuclear fragmentation and membrane blebbing with rounding and detaching from the culture plate unlike control cells

abnormal cell cycle checkpoint function ( J:228492 )

• defective G2/M checkpoint in mouse embryonic fibroblasts treated with tamoxifen

increased apoptosis ( J:228492 )

• in mouse embryonic fibroblasts treated with tamoxifen