Phenotypes associated with this allele

• Allele Symbol: Wee1^tm1.1Cxd
• Allele Name: targeted mutation 1.1, Chu-Xia Deng
• Allele ID: MGI:5707453
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wee1^tm1.1Cxd/Wee1^tm1.1Cxd	involves: 129S6/SvEvTac * FVB/N	MGI:5707475

Genotype
MGI:5707475

hm1

• Allelic Composition: Wee1^tm1.1Cxd/Wee1^tm1.1Cxd
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:228492 )

• fewer than expected mice are detected at E3.5

embryonic lethality between implantation and somite formation, complete penetrance ( J:228492 )

• no mice are present at E7.5

cellular

abnormal cell cycle checkpoint function ( J:228492 )

• partial loss of the G2/M checkpoint induced by gamma-irradiation

increased cellular sensitivity to gamma-irradiation ( J:228492 )

• in E2.0-E2.5 embryos

increased embryonic epiblast cell apoptosis ( J:228492 )

• in embryos between 16-32 cell stages resulting in death

decreased embryonic epiblast cell proliferation ( J:228492 )

• of isolated blastocysts in culture

embryo

increased embryonic epiblast cell apoptosis ( J:228492 )

• in embryos between 16-32 cell stages resulting in death

decreased embryonic epiblast cell proliferation ( J:228492 )

• of isolated blastocysts in culture