Analysis Tools|
Allele Symbol Allele Name Allele ID |
Slc2a9tm1Khm targeted mutation 1.1, Kelle H Moley MGI:5707492 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• significantly increased body fat mass relative to control mice
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• liquid chromatography-mass spectrometry of stool extracts revealed significantly reduced stool urate concentrations relative to controls, suggesting impaired enterocyte uptake and efflux into stool
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• isolated villous enterocytes display a ~65% reduction in [14C]-urate uptake relative to control enterocytes
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• significantly increased body fat mass relative to control mice
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• significantly increased body fat percentage relative to control mice
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• significantly higher serum uric acid concentrations in fasting 6-8-week-old mice
• plasma uric acid levels are significantly decreased following allopurinol treatment
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• ~40% increase in fasting plasma insulin levels relative to controls
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• mice exhibit dyslipidemia, unlike control mice
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• significantly increased total plasma cholesterol levels in fasting mice relative controls
• total plasma cholesterol levels are significantly lowered following allopurinol treatment
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• significantly increased plasma free fatty acid levels in fasting mice relative controls
• fasting free fatty acid levels are not significantly affected by allopurinol treatment
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• significantly increased plasma triglyceride levels in fasting mice relative controls
• fasting triglyceride levels are not significantly affected by allopurinol treatment
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• higher resting energy expenditure relative to control mice, as determined by indirect calorimetry
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• significantly increased volume of inspired oxygen in both 8- and 16-week-old mice relative controls
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• significantly decreased respiratory exchange ratio in 8-week-old mice relative controls
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• signs of early insulin resistance, with an ~40% increase in fasting plasma insulin levels in the context of normal fasting blood glucose and insulin tolerance testing
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• hepatic free fatty acids are elevated in liver homogenates relative to controls
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• hepatic triglycerides are elevated in liver homogenates relative to controls
• hepatic triglyceride content is significantly lowered following allopurinol treatment
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• significantly higher urine uric acid concentrations in fasting 6-8-week-old mice
• urine urate concentrations are not significantly altered by allopurinol treatment
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• mice develop early-onset spontaneous hyperuricemic metabolic syndrome that is partially reversed by allopurinol, a xanthine oxidase inhibitor
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• significantly increased heat production in 8-week-old mice relative controls
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• echocardiography revealed significantly increased basal heart rate, decreased diastolic left ventricular internal diameter with increased relative wall thickness, suggesting cardiac hypertrophic remodeling
• echocardiographic parameters are not significantly altered by allopurinol treatment
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• significantly increased basal heart rate relative to controls, as shown by echocardiography
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• baseline hypertension, as shown by significantly increased systolic, diastolic, and mean blood pressure in non-fasting mice relative controls
• blood pressure is significantly lowered following allopurinol treatment
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• hepatic free fatty acids are elevated in liver homogenates relative to controls
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• hepatic triglycerides are elevated in liver homogenates relative to controls
• hepatic triglyceride content is significantly lowered following allopurinol treatment
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• increased hepatic fat deposition relative to controls
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• significantly higher urine uric acid concentrations in fasting 6-8-week-old mice
• urine urate concentrations are not significantly altered by allopurinol treatment
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| abdominal obesity-metabolic syndrome | DOID:0060611 |
OMIM:PS605552 |
J:221544 | |
| hyperuricemia | DOID:1920 | J:221544 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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