About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ube2j1tm1.2Hpl
targeted mutation 1.2, Hidde Ploegh
MGI:5707498
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ube2j1tm1.2Hpl/Ube2j1tm1.2Hpl involves: BALB/cJ * C57BL/6 * C57BL/6N * SJL MGI:5707924


Genotype
MGI:5707924
hm1
Allelic
Composition
Ube2j1tm1.2Hpl/Ube2j1tm1.2Hpl
Genetic
Background
involves: BALB/cJ * C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ube2j1tm1.2Hpl mutation (0 available); any Ube2j1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal head morphology of Ube2j1tm1.2Hpl/Ube2j1tm1.2Hpl sperm

cellular
• cytoplasm found around the acrosome and neck of sperm
• excess cytoplasm in the midpiece
• expanded subacrosomal space often observed
• 15% of sperm are acephalic
• elongated spermatids persist
• impaired mobility of those sperm produced

mortality/aging
• born at expected ratios
• about half dead by weaning
• mortality is normal after weaning
• survivors are healthy in adulthood

growth/size/body
• surviving mice are smaller in size than controls
• body weight at weaning is significantly less than controls

behavior/neurological
N
• pups nurse normally

immune system
N
• B cell development is normal
• secretion of immunoglobulins is normal

reproductive system
• cytoplasm found around the acrosome and neck of sperm
• excess cytoplasm in the midpiece
• expanded subacrosomal space often observed
• 15% of sperm are acephalic
• elongated spermatids persist
• impaired mobility of those sperm produced
• significantly fewer sperm in the epididymis
• male mice are sterile
• vaginal plugs are produced in females
• unable to fertilize eggs in vitro or fertilized eggs never reach the morula stage





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory