Phenotypes associated with this allele

• Allele Symbol: Ube2j1^tm1.2Hpl
• Allele Name: targeted mutation 1.2, Hidde Ploegh
• Allele ID: MGI:5707498
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ube2j1^tm1.2Hpl/Ube2j1^tm1.2Hpl	involves: BALB/cJ * C57BL/6 * C57BL/6N * SJL	MGI:5707924

Genotype
MGI:5707924

hm1

• Allelic Composition: Ube2j1^tm1.2Hpl/Ube2j1^tm1.2Hpl
• Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal head morphology of Ube2j1^tm1.2Hpl/Ube2j1^tm1.2Hpl sperm

cellular

teratozoospermia ( J:218292 )

♂

abnormal acrosome morphology ( J:218292 )

♂ • cytoplasm found around the acrosome and neck of sperm

♂ • excess cytoplasm in the midpiece

♂ • expanded subacrosomal space often observed

absent sperm head ( J:218292 )

♂ • 15% of sperm are acephalic

abnormal spermatid morphology ( J:218292 )

♂ • elongated spermatids persist

asthenozoospermia ( J:218292 )

♂ • impaired mobility of those sperm produced

mortality/aging

postnatal lethality, incomplete penetrance ( J:218292 )

• born at expected ratios

• about half dead by weaning

• mortality is normal after weaning

• survivors are healthy in adulthood

growth/size/body

decreased body size ( J:218292 )

• surviving mice are smaller in size than controls

decreased body weight ( J:218292 )

• body weight at weaning is significantly less than controls

behavior/neurological

behavior/neurological phenotype ( J:218292 )

N • pups nurse normally

immune system

immune system phenotype ( J:218292 )

N • B cell development is normal

N • secretion of immunoglobulins is normal

reproductive system

teratozoospermia ( J:218292 )

♂

abnormal acrosome morphology ( J:218292 )

♂ • cytoplasm found around the acrosome and neck of sperm

♂ • excess cytoplasm in the midpiece

♂ • expanded subacrosomal space often observed

absent sperm head ( J:218292 )

♂ • 15% of sperm are acephalic

abnormal spermatid morphology ( J:218292 )

♂ • elongated spermatids persist

asthenozoospermia ( J:218292 )

♂ • impaired mobility of those sperm produced

abnormal sperm number ( J:218292 )

♂ • significantly fewer sperm in the epididymis

male infertility ( J:218292 )

♂ • vaginal plugs are produced in females

♂ • male mice are sterile

abnormal fertilization ( J:218292 )

♂ • unable to fertilize eggs in vitro or fertilized eggs never reach the morula stage