Phenotypes associated with this allele

• Allele Symbol: Zscan10^{Gt(285B6)1.1Cmhd}
• Allele Name: gene trap 1.1, Centre for Modeling Human Disease
• Allele ID: MGI:5707638
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zscan10^Gt(285B6)1.1Cmhd/Zscan10^Gt(285B6)1.1Cmhd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:5707686

Genotype
MGI:5707686

hm1

• Allelic Composition: Zscan10^{Gt(285B6)1.1Cmhd}/Zscan10^{Gt(285B6)1.1Cmhd}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced female fertility ( J:221010 )

♀ • female breeding performance drops after a few litters with increasingly runted offspring

cellular

maternal effect ( J:221010 )

♀ • female breeding performance drops after a few litters with increasingly runted offspring

immune system

increased B cell number ( J:221010 )

• increased frequency of MHC class II-expressing B cells

increased mature NK cell number ( J:221010 )

• increased frequency of CD11b-expressing NK cells

abnormal T cell subpopulation ratio ( J:221010 )

• lower CD4+/CD8+ ratio

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:221010 )

• increased frequency of CD25-expressing CD4+ T cells

decreased T cell number ( J:221010 )

decreased spleen weight ( J:221010 )

♀ • slightly in female mice

abnormal IgG level ( J:221010 )

• increased ratio of IgG1/IgG2b

• however, IgE levels are normal

increased IgG1 level ( J:221010 )

increased IgG2b level ( J:221010 )

homeostasis/metabolism

increased circulating creatinine level ( J:221010 )

increased blood urea nitrogen level ( J:221010 )

decreased circulating corticosterone level ( J:221010 )

♂ • in male mice at 16 weeks

decreased circulating calcium level ( J:221010 )

♂ • in male, but not female, mice

increased circulating lactate dehydrogenase level ( J:221010 )

♀ • in female mice

♀ • however, male mice tend to exhibit lower levels

decreased circulating serum albumin level ( J:221010 )

decreased body temperature ( J:221010 )

♂ • tendency to be slightly lower in male mice

decreased circulating chloride level ( J:221010 )

• moderate

respiratory system

decreased tidal volume ( J:221010 )

decreased pulmonary respiratory rate ( J:221010 )

♂ • in male mice

decreased lung compliance ( J:221010 )

skeleton

short tibia ( J:221010 )

♀ • in female mice

decreased bone mineral content ( J:221010 )

♀ • in female mice

decreased bone mass ( J:221010 )

♀ • decreased bone content in female mice

vision/eye

abnormal lens morphology ( J:221010 )

• increased lens density in male left eyes or in female right eyes

cataract ( J:221010 )

• borderline significance

microphthalmia ( J:221010 )

• reduced axial eye lengths

abnormal vision ( J:221010 )

♀ • borderline significant reduction in response to a moving stripe pattern in female mice

♀ • however, male mice exhibit normal response

behavior/neurological

increased startle reflex ( J:221010 )

♀ • increase in acoustic startle reactivity at higher sound pressure levels in female mice

impaired coordination ( J:221010 )

• mice fall off a rotarod more frequently compared with control mice

decreased locomotor activity ( J:221010 )

♂ • male mice exhibit decreased locomoter activity and speed and enter the center less frequently compared with wild-type mice

increased locomotor activity ( J:221010 )

♀ • female mice exhibit increased locomoter activity and speed and enter the center more frequently compared with wild-type mice

cardiovascular system

decreased heart weight ( J:221010 )

♀ • slightly in female mice

abnormal heart left ventricle morphology ( J:221010 )

♂ • increased systolic left ventricular internal dimension in male mice

decreased heart rate ( J:221010 )

growth/size/body

decreased body weight ( J:221010 )

♀ • female mice exhibit a decrease in body weight compared with wild-type mice without a shift in body composition

♀ • however, male mice do not exhibit a significant change in body weight

increased liver weight ( J:221010 )

♂ • in male mice

hematopoietic system

thrombocytopenia ( J:221010 )

increased mean platelet volume ( J:221010 )

increased B cell number ( J:221010 )

• increased frequency of MHC class II-expressing B cells

increased mature NK cell number ( J:221010 )

• increased frequency of CD11b-expressing NK cells

abnormal T cell subpopulation ratio ( J:221010 )

• lower CD4+/CD8+ ratio

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:221010 )

• increased frequency of CD25-expressing CD4+ T cells

decreased T cell number ( J:221010 )

decreased spleen weight ( J:221010 )

♀ • slightly in female mice

abnormal IgG level ( J:221010 )

• increased ratio of IgG1/IgG2b

• however, IgE levels are normal

increased IgG1 level ( J:221010 )

increased IgG2b level ( J:221010 )

limbs/digits/tail

short tibia ( J:221010 )

♀ • in female mice

liver/biliary system

increased liver weight ( J:221010 )

♂ • in male mice

nervous system

increased prepulse inhibition ( J:221010 )

♂ • in male mice

renal/urinary system

increased urination frequency ( J:221010 )

• during SHIRPA testing