Analysis Tools
reproductive system
infertility
(
J:218720
)
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• both male and female mutant mice are infertile
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growth/size/body
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• mutant males are significantly heavier than controls starting at 3 weeks of age
• mutant females are significantly heavier than controls starting at 5 weeks of age
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• mutant mice weigh significantly more than controls by or shortly after weaning and continue to gain weight into adulthood
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homeostasis/metabolism
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• neither male nor female mutant mice produce any detectable circulating serum leptin levels
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• primary pituitary cells derived from adult mutant mice exhibit very few cells that are immunopositive for leptin relative to control pituitary cells
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• adult male, but not female, mutants exhibit significantly decreased circulating FSH levels relative to controls
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• adult female, but not male, mutants exhibit significantly decreased circulating prolactin levels relative to controls
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endocrine/exocrine glands
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• primary pituitary cells derived from adult mutant mice show a significant decrease in the % of cells immunolabeled for growth hormone (GH) relative to control pituitary cells
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nervous system
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• primary pituitary cells derived from adult mutant mice show a significant decrease in the % of cells immunolabeled for growth hormone (GH) relative to control pituitary cells
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