All Phenotypes Fgfrl1<tm2.1True> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgfrl1^tm2.1True
targeted mutation 2.1, Beat Trueb
MGI:5707709

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfrl1^tm2.1True/Fgfrl1^tm2.1True	B6.Cg-Fgfrl1^tm2.1True	MGI:5762557
ht2	Fgfrl1^tm2.1True/Fgfrl1⁺	B6.Cg-Fgfrl1^tm2.1True	MGI:5762558
ht3	Fgfrl1^tm1True/Fgfrl1^tm2.1True	B6.Cg-Fgfrl1^tm1True Fgfrl1^tm2.1True	MGI:5762560

Allelic Composition	Fgfrl1^tm2.1True/Fgfrl1^tm2.1True
Genetic Background	B6.Cg-Fgfrl1^tm2.1True

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfrl1^tm2.1True mutation (0 available); any Fgfrl1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Morphology of kidneys in heterozygous and homozygous Fgfrl1^tm2.1True mice

renal/urinary system

decreased renal glomerulus number ( J:218981 )

• at E17.5, homozygotes display a slight but significant reduction in the total number of glomeruli relative to wild-type controls

mortality/aging

mortality/aging ( J:218981 )

N	• surprisingly, homozygotes are viable and do not exhibit any overt malformations • one male homozygote survived for >18 months with no apparent pathology

muscle

muscle phenotype ( J:218981 )

N	• surprisingly, diaphragm morphology is normal at E18.5, as shown by H&E staining

skeleton

skeleton phenotype ( J:218981 )

N	• surprisingly, the skull and long bones appear morphologically normal at E18.5, as shown by alcian/alizarin staining

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:218981 )

N	• contrary to expectation, production of insulin by pancreatic beta-cells is normal at E18.5 • no signs of hyperglycemia are observed

Allelic Composition	Fgfrl1^tm2.1True/Fgfrl1⁺
Genetic Background	B6.Cg-Fgfrl1^tm2.1True

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfrl1^tm2.1True mutation (0 available); any Fgfrl1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Morphology of kidneys in heterozygous and homozygous Fgfrl1^tm2.1True mice

renal/urinary system

decreased renal glomerulus number ( J:218981 )

• at E17.5, heterozygotes display a slight but significant reduction in the total number of glomeruli relative to wild-type controls

• however, both survival and overall phenotype remain normal

Allelic Composition	Fgfrl1^tm1True/Fgfrl1^tm2.1True
Genetic Background	B6.Cg-Fgfrl1^tm1True Fgfrl1^tm2.1True

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfrl1^tm1True mutation (0 available); any Fgfrl1 mutation (30 available)
Fgfrl1^tm2.1True mutation (0 available); any Fgfrl1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:218981 )

• mice are viable, fertile and phenotypically normal; one male survived for >21 months

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