All Phenotypes Fgfrl1<tm2.1True> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgfrl1^tm2.1True
targeted mutation 2.1, Beat Trueb
MGI:5707709

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfrl1^tm2.1True/Fgfrl1^tm2.1True	B6.Cg-Fgfrl1^tm2.1True	MGI:5762557
ht2	Fgfrl1^tm2.1True/Fgfrl1⁺	B6.Cg-Fgfrl1^tm2.1True	MGI:5762558
ht3	Fgfrl1^tm1True/Fgfrl1^tm2.1True	B6.Cg-Fgfrl1^tm1True Fgfrl1^tm2.1True	MGI:5762560

Allelic Composition	Fgfrl1^tm2.1True/Fgfrl1^tm2.1True
Genetic Background	B6.Cg-Fgfrl1^tm2.1True

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfrl1^tm2.1True mutation (0 available); any Fgfrl1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Morphology of kidneys in heterozygous and homozygous Fgfrl1^tm2.1True mice

renal/urinary system

decreased renal glomerulus number ( J:218981 )

• at E17.5, homozygotes display a slight but significant reduction in the total number of glomeruli relative to wild-type controls

mortality/aging

mortality/aging ( J:218981 )

N	• surprisingly, homozygotes are viable and do not exhibit any overt malformations • one male homozygote survived for >18 months with no apparent pathology

muscle

muscle phenotype ( J:218981 )

N	• surprisingly, diaphragm morphology is normal at E18.5, as shown by H&E staining

skeleton

skeleton phenotype ( J:218981 )

N	• surprisingly, the skull and long bones appear morphologically normal at E18.5, as shown by alcian/alizarin staining

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:218981 )

N	• contrary to expectation, production of insulin by pancreatic beta-cells is normal at E18.5 • no signs of hyperglycemia are observed

Allelic Composition	Fgfrl1^tm2.1True/Fgfrl1⁺
Genetic Background	B6.Cg-Fgfrl1^tm2.1True

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfrl1^tm2.1True mutation (0 available); any Fgfrl1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Morphology of kidneys in heterozygous and homozygous Fgfrl1^tm2.1True mice

renal/urinary system

decreased renal glomerulus number ( J:218981 )

• at E17.5, heterozygotes display a slight but significant reduction in the total number of glomeruli relative to wild-type controls

• however, both survival and overall phenotype remain normal

Allelic Composition	Fgfrl1^tm1True/Fgfrl1^tm2.1True
Genetic Background	B6.Cg-Fgfrl1^tm1True Fgfrl1^tm2.1True

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfrl1^tm1True mutation (0 available); any Fgfrl1 mutation (30 available)
Fgfrl1^tm2.1True mutation (0 available); any Fgfrl1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:218981 )

• mice are viable, fertile and phenotypically normal; one male survived for >21 months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24