Analysis Tools
behavior/neurological
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• significantly less time spent in the open arms than wild-type controls in an elevated plus maze test at 3-4 months of age
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• reduced acoustic startle responses to tones greater than or equal to 110 dB (significant at 110 dB only) at 3-4 months of age
• however, startle responses to tones less than 110 dB and the prepulse inhibition (PPI) of the startle response are similar to those of wild-type controls
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• fewer ambulatory bouts than wild-type controls in an open field test at 3-4 months of age
• however, average speed of locomotion during ambulatory bouts is normal
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• signicantly less vertical activity counts than wild-type controls in an open eld test at 3-4 months of age
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• decreased spontaneous locomotor activity in an open field test, with significantly less distance travelled than wild-type controls at 3-4 months of age
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nervous system
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N |
• grossly normal neonatal brain morphology and size
• no obvious alterations in neuronal subpopulations on cortical slices at E16
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