Phenotypes associated with this allele

• Allele Symbol: Pla2g7^tm1.1Mcap
• Allele Name: targeted mutation 1.1, Michael Caplan
• Allele ID: MGI:5707934
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2g7^tm1.1Mcap/Pla2g7^tm1.1Mcap	B6.Cg-Pla2g7^tm1.1Mcap	MGI:5707973

Genotype
MGI:5707973

hm1

• Allelic Composition: Pla2g7^tm1.1Mcap/Pla2g7^tm1.1Mcap
• Genetic Background: B6.Cg-Pla2g7^tm1.1Mcap

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:228564 )

• mice are subjected to experimental treatment including asphyxia, formula feeding and bacterial supplementation with Serratia marcescens and Streptococcus viridans

• lower incidence of early death (within 24 hours) relative to controls

immune system

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:228564 )

• mice are subjected to experimental treatment including asphyxia, formula feeding and bacterial supplementation with Serratia marcescens and Streptococcus viridans

• lower incidence of early death (within 24 hours) relative to controls

increased susceptibility to bacterial infection ( J:228564 )

• mice are subjected to experimental treatment including asphyxia, formula feeding and bacterial supplementation with Serratia marcescens and Streptococcus viridans

• increased incidence of necrotizing enterocolitis compared to controls

• 43% of mice develop the condition

• injury is primarily in the ileum and proximal colon