All Phenotypes Hdac11<tm1.2Mrl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hdac11^tm1.2Mrl
targeted mutation 1.2, Merck Research Laboratory
MGI:5707970

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hdac11^tm1.2Mrl/Hdac11^tm1.2Mrl	involves: C57BL/6NTac	MGI:5708042

Allelic Composition	Hdac11^tm1.2Mrl/Hdac11^tm1.2Mrl
Genetic Background	involves: C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac11^tm1.2Mrl mutation (1 available); any Hdac11 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interferon-gamma secretion ( J:222335 )

• in a EL4 tumor challenge using OT-I responder cells and ovalbumin peptide stimulation, myeloid-derived suppressive cells exhibit reduced IFN-gamma production compared with wild-type cells

increased interleukin-10 secretion ( J:228570 )

• from peritoneal elicited macrophages (PEM) in response to LPS

• however, knock-down of HDAC6 abolishes IL10 production

neoplasm

increased tumor growth/size ( J:222335 )

• of EL4 or Panco tumors injected into mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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