Phenotypes associated with this allele

• Allele Symbol: Retsat^tm1Kpal
• Allele Name: targeted mutation 1, Krzysztof Palczewski
• Allele ID: MGI:5708113
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Retsat^tm1Kpal/Retsat^tm1Kpal	involves: 129 * C57BL/6	MGI:5779929

Genotype
MGI:5779929

hm1

• Allelic Composition: Retsat^tm1Kpal/Retsat^tm1Kpal
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:222367 )

N • normal insulin resistance and glucose tolerance in mice fed normal chow

abnormal vitamin A metabolism ( J:222367 )

• mice are unable to convert all-trans-retinol (atROL) to (R)-all-trans-13,14-dihydroretinol (DROL) and are thus deficient in dihydroretinoid production from dietary vitamin A

• analysis of hepatic nonpolar retinoids by HPLC coupled to UV detection confirmed absence of DROL in liver tissue of mutant mice gavaged with retinyl palmitate

• however, levels of retinol and retinyl palmitate in liver, serum, and adipose tissue are normal on a low-fat diet (LFD) containing 10 kcal % fat and 4 IU vitamin A/g diet

adipose tissue

abnormal adipose tissue development ( J:222367 )

• increased expression of key adipogenic markers in mice maintained on a HFD relative to wild-type controls

abnormal abdominal fat pad morphology ( J:222367 )

• increase in the volume of visceral adipose stores in mice maintained on a HFD relative to wild-type controls

abnormal inguinal fat pad morphology ( J:222367 )

• increase in the volume of inguinal adipose stores in mice maintained on a HFD relative to wild-type controls

increased percent body fat/body weight ( J:222367 )

• increased adiposity (as % of total body weight) in both male and female mice maintained on a high-fat diet (HFD) containing 45 kcal % fat for 10 weeks relative to sex-matched wild-type controls

• however, no differences in food intake, body weight, and liver or adipocyte morphology are observed on a HFD relative to wild-type controls

growth/size/body

growth/size/body region phenotype ( J:222367 )

N • mice fed either a low-fat diet (LFD) or a HFD gain weight at a similar rate as wild-type controls