Phenotypes associated with this allele

• Allele Symbol: Mtpap^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5708206
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtpap^tm1.1(KOMP)Vlcg/Mtpap^tm1.1(KOMP)Vlcg	C57BL/6N-Mtpap^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:6325157
ht2	Mtpap^tm1.1(KOMP)Vlcg/Mtpap^+	C57BL/6N-Mtpap^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:6288587

Genotype
MGI:6325157

hm1

• Allelic Composition: Mtpap^{tm1.1(KOMP)Vlcg}/Mtpap^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Mtpap^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 18912A-B2

Data Sources

IMPC Data for Mtpap

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mtpap^{tm1.1(KOMP)Vlcg}/Mtpap^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

embryo

failure to gastrulate ( J:290315 , J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are present at E7.5 (19% versus expected 25%, n=19); no homozygous embryos are recovered at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:6288587

ht2

• Allelic Composition: Mtpap^{tm1.1(KOMP)Vlcg}/Mtpap⁺
• Genetic Background: C57BL/6N-Mtpap^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 18912A-B2

Data Sources

IMPC Data for Mtpap

behavior/neurological

abnormal locomotor behavior ( J:211773 )

IMPC - UCD

hyperactivity ( J:211773 )

IMPC - UCD

cardiovascular system

abnormal heart morphology ( J:211773 )

♀

IMPC - UCD

enlarged heart ( J:211773 )

♀

IMPC - UCD

growth/size/body

enlarged heart ( J:211773 )

♀

IMPC - UCD

hematopoietic system

increased erythrocyte cell number ( J:211773 )

IMPC - UCD

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♀

IMPC - UCD

nervous system

small superior vagus ganglion ( J:211773 )

♀

IMPC - UCD

reproductive system

hydrometra ( J:211773 )

♀

IMPC - UCD