All Phenotypes Mtpap<tm1.1(KOMP)Vlcg> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mtpap^{tm1.1(KOMP)Vlcg}/Mtpap^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

embryo

failure to gastrulate ( J:290315 , J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are present at E7.5 (19% versus expected 25%, n=19); no homozygous embryos are recovered at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Allelic Composition	Mtpap^{tm1.1(KOMP)Vlcg}/Mtpap⁺
Genetic Background	C57BL/6N-Mtpap^{tm1.1(KOMP)Vlcg}/MbpMmucd
Cell Lines	18912A-B2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtpap^{tm1.1(KOMP)Vlcg} mutation (1 available); any Mtpap mutation (30 available)

Data Sources

IMPC Data for Mtpap

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:211773 )

IMPC - UCD

hyperactivity ( J:211773 )

IMPC - UCD

hematopoietic system

increased erythrocyte cell number ( J:211773 )

IMPC - UCD

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

IMPC - UCD

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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