All Phenotypes Fam72a<tm1.1(KOMP)Vlcg> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Fam72a^{tm1.1(KOMP)Vlcg}/Fam72a^{tm1.1(KOMP)Vlcg}
Genetic Background	C57BL/6N-Fam72a^{tm1.1(KOMP)Vlcg}/Ucd
Cell Lines	14033A-B10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam72a^{tm1.1(KOMP)Vlcg} mutation (1 available); any Fam72a mutation (30 available)

Data Sources

IMPC Data for Fam72a

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

polycystic kidney ( J:211773 )

IMPC - UCD

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

IMPC - UCD

polycystic kidney ( J:211773 )

IMPC - UCD

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell apoptosis ( J:326431 )

• slight in mice immunized with NP-CGG

abnormal class switch recombination ( J:326431 )

• impaired for all immunoglobulin isotypes in isolated splenic B cells

• impaired in mice immunized with nitro-phenyl-chicken gamma globulin (NP-CGG)

• however, mice treated with NP-CGG exhibit normal germinal center size, and T follicular helper cell numbers

abnormal somatic hypermutation frequency ( J:326431 )

• impaired

increased germinal center B cell number ( J:326431 )

• slightly in mice immunized with NP-CGG

• however, germinal center size is normal

cellular

increased B cell apoptosis ( J:326431 )

• slight in mice immunized with NP-CGG

hematopoietic system

increased B cell apoptosis ( J:326431 )

• slight in mice immunized with NP-CGG

abnormal class switch recombination ( J:326431 )

• impaired for all immunoglobulin isotypes in isolated splenic B cells

• impaired in mice immunized with nitro-phenyl-chicken gamma globulin (NP-CGG)

• however, mice treated with NP-CGG exhibit normal germinal center size, and T follicular helper cell numbers

abnormal somatic hypermutation frequency ( J:326431 )

• impaired

increased germinal center B cell number ( J:326431 )

• slightly in mice immunized with NP-CGG

• however, germinal center size is normal

Allelic Composition	Fam72a^{tm1.1(KOMP)Vlcg}/Fam72a^{tm1.1(KOMP)Vlcg} Msh2^tm1Mak/Msh2^tm1Mak
Genetic Background	C57BL/6NTac-Fam72a^{tm1.1(KOMP)Vlcg} Msh2^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam72a^{tm1.1(KOMP)Vlcg} mutation (1 available); any Fam72a mutation (30 available)
Msh2^tm1Mak mutation (1 available); any Msh2 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:326431 )

• impaired

abnormal somatic hypermutation frequency ( J:326431 )

• impaired

hematopoietic system

abnormal class switch recombination ( J:326431 )

• impaired

abnormal somatic hypermutation frequency ( J:326431 )

• impaired

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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