Analysis Tools
cardiovascular system
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• untreated mice are healthy and show no apparent cardiac pathologies, as determined by the heart weight/body weight ratio, cardiac chamber structure, cardiomyocyte cross-sectional area, and cardiac capillary density
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• when Evans blue dye is i.v. injected at 20 h after i.p. LPS injection, 8-week-old male mice show poorer peripheral circulation (less dye on lips and extremities), more organ edema in their lungs and intestine (as determined by a higher of wet weight/dry weight ratio), and significantly increased dye extravasation in their hearts, aortas, lungs, intestine, and stomach relative to LPS-treated wild-type controls
• however, no differences in organ edema or EB dye extravasation are detected in the liver, spleen, and kidney
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immune system
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• at 20 h after i.p. LPS injection, mice show a significantly higher total lung injury score, aggravated intestine injury with a marked decrease in villus length and a higher Chius score, and more severe cardiac dysfunction with a significantly lower left ventricular ejection fraction (EF%) and fractional shortening (FS%) than LPS-treated wild-type controls
• at 96 h post-LPS injection, mice show a significantly lower survival rate (10%) than LPS-treated wild-type controls (40%)
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mortality/aging
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• at 96 h post-LPS injection, mice show a significantly lower survival rate (10%) than LPS-treated wild-type controls (40%)
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