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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kcnt1tm1.2Acsc
targeted mutation 1.2, Achim Schmidtko
MGI:5708322
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kcnt1tm1.2Acsc/Kcnt1tm1.2Acsc involves: 129 * C57BL/6N MGI:7624384
hm2
Kcnt1tm1.2Acsc/Kcnt1tm1.2Acsc B6N.Cg-Kcnt1tm1.2Acsc MGI:5896603


Genotype
MGI:7624384
hm1
Allelic
Composition
Kcnt1tm1.2Acsc/Kcnt1tm1.2Acsc
Genetic
Background
involves: 129 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1tm1.2Acsc mutation (0 available); any Kcnt1 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• no spontaneous electrographic seizures or behavioral seizures
• normal spatial learning in Lashley III maze test
• impaired motor learning in rotarod test
• less distance traveled in open field test
• severely reduced mortality rate from electroshock seizures
• slightly reduced electroshock seizure threshold

nervous system
• slightly reduced electroshock seizure threshold
• severely reduced mortality rate from electroshock seizures




Genotype
MGI:5896603
hm2
Allelic
Composition
Kcnt1tm1.2Acsc/Kcnt1tm1.2Acsc
Genetic
Background
B6N.Cg-Kcnt1tm1.2Acsc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1tm1.2Acsc mutation (0 available); any Kcnt1 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduced sodium-activated potassium currents in sensory neurons

behavior/neurological
• increased mechanical hypersensitivity after spared nerve injury or treatment with paclitaxel used to induce a neuropathic pain model
• however, basal pain sensitivity is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory