Phenotypes associated with this allele

• Allele Symbol: Kcnt1^tm1.2Acsc
• Allele Name: targeted mutation 1.2, Achim Schmidtko
• Allele ID: MGI:5708322
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnt1^tm1.2Acsc/Kcnt1^tm1.2Acsc	involves: 129 * C57BL/6N	MGI:7624384
hm2	Kcnt1^tm1.2Acsc/Kcnt1^tm1.2Acsc	B6N.Cg-Kcnt1^tm1.2Acsc	MGI:5896603

Genotype
MGI:7624384

hm1

• Allelic Composition: Kcnt1^tm1.2Acsc/Kcnt1^tm1.2Acsc
• Genetic Background: involves: 129 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:287751 )

N • no spontaneous electrographic seizures or behavioral seizures

N • normal spatial learning in Lashley III maze test

abnormal motor learning ( J:287751 )

• impaired motor learning in rotarod test

decreased locomotor activity ( J:287751 )

• less distance traveled in open field test

abnormal seizure response to electrical stimulation ( J:287751 )

• slightly reduced electroshock seizure threshold

• severely reduced mortality rate from electroshock seizures

nervous system

abnormal seizure response to electrical stimulation ( J:287751 )

• slightly reduced electroshock seizure threshold

• severely reduced mortality rate from electroshock seizures

Genotype
MGI:5896603

hm2

• Allelic Composition: Kcnt1^tm1.2Acsc/Kcnt1^tm1.2Acsc
• Genetic Background: B6N.Cg-Kcnt1^tm1.2Acsc

nervous system

impaired ability to fire action potentials ( J:218978 )

• in sensory neurons

abnormal sensory neuron physiology ( J:218978 )

• reduced sodium-activated potassium currents in sensory neurons

behavior/neurological

abnormal mechanical nociception ( J:218978 )

• increased mechanical hypersensitivity after spared nerve injury or treatment with paclitaxel used to induce a neuropathic pain model

• however, basal pain sensitivity is normal