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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1.1Umol
targeted mutation 1.1, Ute Moll
MGI:5708402
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm1.1Umol/Trp53tm1.1Umol involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac MGI:5790355
ht2
 		Trp53tm1Tyj/Trp53tm1.1Umol involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac MGI:5790354


Genotype
MGI:5790355
hm1
Allelic
Composition		 Trp53tm1.1Umol/Trp53tm1.1Umol
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1.1Umol mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:228632 )
• shortened survival compared to single Trp53tm1Tyj homozygotes

neoplasm
increased T cell derived lymphoma incidence ( J:228632 )
• accelerated tumor onset of T lymphomas compared to single Trp53tm1Tyj homozygotes
increased B cell derived lymphoma incidence ( J:228632 )
• accelerated tumor onset of B lymphomas compared to single Trp53tm1Tyj homozygotes
decreased tumor latency ( J:228632 )
• accelerated tumor onset of T lymphomas, B lymphomas, and solid tumors compared to single Trp53tm1Tyj homozygotes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:228632 )
• accelerated tumor onset of T lymphomas compared to single Trp53tm1Tyj homozygotes

hematopoietic system
increased T cell derived lymphoma incidence ( J:228632 )
• accelerated tumor onset of T lymphomas compared to single Trp53tm1Tyj homozygotes

immune system
increased T cell derived lymphoma incidence ( J:228632 )
• accelerated tumor onset of T lymphomas compared to single Trp53tm1Tyj homozygotes




Genotype
MGI:5790354
ht2
Allelic
Composition		 Trp53tm1Tyj/Trp53tm1.1Umol
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1.1Umol mutation (0 available); any Trp53 mutation (240 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:228632 )
• shortened survival compared to single Trp53tm1Tyj homozygotes

neoplasm
increased leukemia incidence ( J:228632 )
• T-lymphoma cell lines established from mutant mice develop into highly aggressive leukemias when tail vein injected into the circulation of nude mice
increased lymphoma incidence ( J:228632 )
• lymphomas show a 2-fold increase in cell proliferation compared to lymphomas from Trp53tm1Tyj homozygotes and compound heterozygous Trp53tm2.1Umol/Trp53tm1Tyj mice
increased T cell derived lymphoma incidence ( J:228632 )
• accelerated tumor onset of T lymphomas compared to single Trp53tm1Tyj homozygotes
increased B cell derived lymphoma incidence ( J:228632 )
• accelerated tumor onset of B lymphomas compared to single Trp53tm1Tyj homozygotes
increased carcinoma incidence ( J:228632 )
• mice show broadening of the tumor spectrum, showing more carcinomas compared with single Trp53tm1Tyj homozygotes
increased sarcoma incidence ( J:228632 )
• mice show broadening of the tumor spectrum, showing a higher diversity of sarcoma subtypes compared with single Trp53tm1Tyj homozygotes
increased reproductive system tumor incidence ( J:228632 )
• mice show broadening of the tumor spectrum, showing more germ cell tumors compared with single Trp53tm1Tyj homozygotes
decreased tumor latency ( J:228632 )
• accelerated tumor onset of T lymphomas, B lymphomas, and solid tumors compared to single Trp53tm1Tyj homozygotes

cellular
decreased cellular sensitivity to gamma-irradiation ( J:228632 )
• thymocytes are resistant to apoptosis after gamma-irradiation

embryo
abnormal mesenchyme morphology ( J:228632 )
• mice show a similar expansion of mesenchymal stem cells as single Trp53tm1Tyj homozygotes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:228632 )
• accelerated tumor onset of T lymphomas compared to single Trp53tm1Tyj homozygotes

hematopoietic system
increased T cell derived lymphoma incidence ( J:228632 )
• accelerated tumor onset of T lymphomas compared to single Trp53tm1Tyj homozygotes
increased hematopoietic stem cell number ( J:228632 )
• mice show a greater increase in the number of hematopoietic Lin-Sca1+c-Kit+ (LSK) progenitor cells than single Trp53tm1Tyj homozygotes

reproductive system
increased reproductive system tumor incidence ( J:228632 )
• mice show broadening of the tumor spectrum, showing more germ cell tumors compared with single Trp53tm1Tyj homozygotes

immune system
increased T cell derived lymphoma incidence ( J:228632 )
• accelerated tumor onset of T lymphomas compared to single Trp53tm1Tyj homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory