Phenotypes associated with this allele

• Allele Symbol: Gch1^tm1.2Drg
• Allele Name: targeted mutation 1.2, David Greaves
• Allele ID: MGI:5708509
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gch1^tm1.2Drg/Gch1^tm1.2Drg	involves: C57BL/6J	MGI:5896987

Genotype
MGI:5896987

hm1

• Allelic Composition: Gch1^tm1.2Drg/Gch1^tm1.2Drg
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:219813 )

• die between E11.5 and E13.5

• supplementation with both L-DOPA and sepiapterin improves survival but does not fully rescue

cardiovascular system

decreased heart rate ( J:219813 )

• at E11.5 in 7 of 12 surviving null mice

homeostasis/metabolism

decreased dopamine level ( J:219813 )

• decrease in L-DOPA levels at E11.5