Analysis Tools
mortality/aging
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• only 8 of 128 mice delivered survived to adulthood
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• most (120 of 128) mice die between P0.5 and P2
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growth/size/body
malocclusion
(
J:219788
)
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• at 2 months of age, 2 of 8 survivors display malocclusion
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• at 2 months of age, 2 of 8 survivors display an obviously bent nose
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• starting at E10.5
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• all mice are born smaller in size
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• mice surviving to adulthood show severe growth retardation within the first 4 weeks after birth
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• at E14.5-E18.5
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• mice show growth retardation as early as E10.5
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behavior/neurological
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• pups lack gastric milk, suggesting death from starvation
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• although pups are capable of actively searching and licking their mothers' nipples, they fail to remain stably attached to the nipples for even just 1 min in ~70% of attempts
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skeleton
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• at 2 months of age, rare survivors display bone loss in metopic sutures
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malocclusion
(
J:219788
)
|
• at 2 months of age, 2 of 8 survivors display malocclusion
|
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• at 2 months of age, 2 of 8 survivors display an obviously bent nose
|
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• at P0, neonates show delayed ossification at the nasal bones and sagittal and metopic sutures
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craniofacial
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• at 2 months of age, rare survivors display bone loss in metopic sutures
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malocclusion
(
J:219788
)
|
• at 2 months of age, 2 of 8 survivors display malocclusion
|
|
• at 2 months of age, 2 of 8 survivors display an obviously bent nose
|
cellular
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• ESCs derived from mutant mice fail to efficiently establish H3K9me2 during retinoic acid-induced differentiation across a large number of genes, and a subset of these genes, including Oct4 and Nanog, display delayed gene silencing during differentiation
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embryo
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• starting at E10.5
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respiratory system
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• at 2 months of age, 2 of 8 survivors display an obviously bent nose
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