Phenotypes associated with this allele

• Allele Symbol: Abcb10^tm1.1Tafu
• Allele Name: targeted mutation 1.1, Tatsuhiko Furukawa
• Allele ID: MGI:5708653
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Abcb10^tm1.1Tafu/Abcb10^tm1.2Tafu Tg(Mx1-cre)1Cgn/0	involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ	MGI:5749139

Genotype
MGI:5749139

cn1

• Allelic Composition: Abcb10^tm1.1Tafu/Abcb10^tm1.2Tafu; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial morphology ( J:223428 )

• bone marrow cell mitochondria of pI-pC treated mice show prominent contours of the membranes and are swollen

• accumulation of iron in mitochondria of bone marrow cells of pI-pC treated mice

hematopoietic system

abnormal erythropoiesis ( J:223428 )

• pI-pC treated mice show impaired erythroid cell maturation

hypochromic microcytic anemia ( J:223428 )

• pI-pC treated mice develop anemia; anemia is classified as microcytic and hypochromic type

decreased erythrocyte cell number ( J:223428 )

• pI-pC treated mice exhibit a decrease in red blood cell number

abnormal hemoglobin ( J:223428 )

• heme is reduced in the peripheral blood of pI-pC treated mice

decreased hemoglobin content ( J:223428 )

• pI-pC treated mice show a decrease in hemoglobin

• however, white blood cell number and platelet count are normal

decreased mean corpuscular hemoglobin concentration ( J:223428 )

• low mean corpuscular hemoglobin concentration in pI-pC treated mice

decreased mean corpuscular volume ( J:223428 )

• low mean corpuscular volume in pI-pC treated mice

reticulocytosis ( J:223428 )

• pI-pC treated mice show an increase in the number of reticulocytes

homeostasis/metabolism

abnormal iron level ( J:223428 )

• pI-pC treated mice exhibit accumulation of iron in mitochondria