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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr18tm1.1Cys
targeted mutation 1.1, Jason G Cyster
MGI:5708707
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr18tm1.1Cys/Gpr18tm1.1Cys involves: C57BL/6 MGI:5750103


Genotype
MGI:5750103
hm1
Allelic
Composition		 Gpr18tm1.1Cys/Gpr18tm1.1Cys
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr18tm1.1Cys mutation (0 available); any Gpr18 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:219661 )
N
• normal numbers of alpha/beta and gamma/delta T cells and B cells
• lymphocyte development in thymus and bone marrow is normal
decreased CD8-positive, alpha-beta T cell number ( J:219661 )
• deficiencies in CD8alphaalpha and CD8alphabeta alpha-beta T cells
decreased CD8-positive, gamma-delta intraepithelial T cell number ( J:219661 )
• intestinal intraepithelial lymphocytes are deficient in CD8alphaalpha gamma-delta T cells

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:219661 )
• deficiencies in CD8alphaalpha and CD8alphabeta alpha-beta T cells
decreased CD8-positive, gamma-delta intraepithelial T cell number ( J:219661 )
• intestinal intraepithelial lymphocytes are deficient in CD8alphaalpha gamma-delta T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory