Analysis Tools
immune system
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• normal thymocyte, splenocyte, bone-marrow cell, and mesenteric lymphocyte development, as shown by flow cytometric analysis
• normal cytokine production following stimulation of thymocytes and splenocytes with anti-CD3 and anti-CD28 antibodies
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• expanded thymus cortex region with increased lymphocyte density
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• significantly increased thymus to body weight ratio at 7 weeks of age
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• significantly increased spleen to body weight ratio at 7 weeks of age
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• increased lymphocytic density in the spleen white pulp region at 7 weeks of age
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• reduced lymphocytic density in mesenteric lymph nodes at 7 weeks of age
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• grossly enlarged (hypertrophic) mesenteric lymph nodes at 7 weeks of age
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• hypertrophy of lymphoid organs at 7 weeks of age
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hematopoietic system
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• expanded thymus cortex region with increased lymphocyte density
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• significantly increased thymus to body weight ratio at 7 weeks of age
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• significantly increased spleen to body weight ratio at 7 weeks of age
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• increased lymphocytic density in the spleen white pulp region at 7 weeks of age
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endocrine/exocrine glands
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• expanded thymus cortex region with increased lymphocyte density
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• significantly increased thymus to body weight ratio at 7 weeks of age
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growth/size/body
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N |
• normal body weight at 7 weeks of age
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• significantly increased spleen to body weight ratio at 7 weeks of age
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cardiovascular system
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N |
• normal heart morphology and heart to body weight ratio at 7 weeks of age
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nervous system
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N |
• normal brain to body weight ratio at 7 weeks of age
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renal/urinary system
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N |
• normal kidney to body weight ratio at 7 weeks of age
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