Phenotypes associated with this allele

• Allele Symbol: Crb3^tm1.2Lprs
• Allele Name: targeted mutation 1.2, Patrick Laprise
• Allele ID: MGI:5749426
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crb3^tm1.2Lprs/Crb3^tm1.2Lprs	B6(Cg)-Crb3^tm1.2Lprs	MGI:5749501

Genotype
MGI:5749501

hm1

• Allelic Composition: Crb3^tm1.2Lprs/Crb3^tm1.2Lprs
• Genetic Background: B6(Cg)-Crb3^tm1.2Lprs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:228786 )

• pups do not survive beyond postnatal day 1

homeostasis/metabolism

cyanosis ( J:228786 )

digestive/alimentary system

abnormal small intestinal villus morphology ( J:228786 )

• villi form ectopic multilayered epithelial structures

fused small intestinal villi ( J:228786 )

• fused villi are observed in intestinal epithelium of E18.5 embryos

renal/urinary system

polycystic kidney ( J:228786 )

• polycystic kidneys are found in E18.5 embryos, however, number of cilia is similar to controls

abnormal kidney epithelium morphology ( J:228786 )

• cell polarity defects are observed in kidney epithelial cells from E18.5 embryos

• in particular, several apical proteins do not localize to apical domain

renal interstitial fibrosis ( J:228786 )

• a loose interstitial tissue surrounds cysts

small kidney ( J:228786 )

• kidneys are slightly smaller in E18.5 embryos than wild-type embryos, however, difference in kidney weight is not statistically significant

respiratory system

abnormal lung epithelium morphology ( J:228786 )

• minor polarity defects in the apical-basal axis of lung epithelium of E18.5 embryos

abnormal respiratory conducting tube morphology ( J:228786 )

• lungs from E18.5 embryos exhibit atrophied luminal spaces

impaired mucociliary clearance ( J:228786 )

• E18.5 embryos exhibit an accumulation of mucus in airways

respiratory distress ( J:228786 )

• P1 pups exhibit arrhythmic breathing, chest spasms and cyanosis

growth/size/body

polycystic kidney ( J:228786 )

• polycystic kidneys are found in E18.5 embryos, however, number of cilia is similar to controls