Analysis Tools
behavior/neurological
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• 16 month old mice do worse in memory retention (probe) test of the Morris water maze
• however, mice show no differences in motor function or activity
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• 16 month old mice take longer to learn the task in the acquisition test of the Morris water maze indicating impaired place learning
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• 16 month old mice show decreased spontaneous alternation in the Y-maze indicating impaired working memory
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• 16 month old mice spend more time in the open arms of the elevated plus maze test than controls, indicating impaired anxiety
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cellular
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• living old mice show decreased glucose metabolism in the nucleus accumbens
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nervous system
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• 16 month old mice show loss of synapses and dendritic spines in the nucleus accumbens
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• mice exhibit axonal dilatations primarily in cortical layers V and VI of the prefrontal cortex with aging, as well as in the sensorimotor cortex and the orbitofrontal cortex
• however, mice do not exhibit formation of tau aggregates or neurofibrillary tangles and show no signs of neuronal loss, astrogliosis, or microglial proliferation
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• 16 month old mice show loss of dendritic spines in the nucleus accumbens
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• 16 month old mice show loss of synapses in the nucleus accumbens
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| frontotemporal dementia | DOID:9255 |
OMIM:600274 |
J:172762 | |
