Phenotypes associated with this allele

• Allele Symbol: Cdin1^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5749789
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdin1^em1(IMPC)J/Cdin1^em1(IMPC)J	C57BL/6NJ-Cdin1^em1(IMPC)J/J	MGI:6261958
ht2	Cdin1^em1(IMPC)J/Cdin1^+	C57BL/6NJ-Cdin1^em1(IMPC)J/J	MGI:6261957

Genotype
MGI:6261958

hm1

• Allelic Composition: Cdin1^em1(IMPC)J/Cdin1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Cdin1^em1(IMPC)J/J

Data Sources

IMPC Data for Cdin1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cdin1^em1(IMPC)J/Cdin1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form typical outgrowth colonies.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• although normal looking blastocysts are present in relatively normal Mendelian ratios at E3.5 (18% versus expected 25%, n=28), no homozygous embryos or excess resorption sites are observed at E7.5

• in vitro, blastocysts hatch from the zona pellucida and form typical outgrowth colonies after 3 days in culture

Genotype
MGI:6261957

ht2

• Allelic Composition: Cdin1^em1(IMPC)J/Cdin1⁺
• Genetic Background: C57BL/6NJ-Cdin1^em1(IMPC)J/J

Data Sources

IMPC Data for Cdin1

behavior/neurological

abnormal startle reflex ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♀

IMPC - JAX