Analysis Tools
cardiovascular system
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• mice injected with tamoxifen at P1-P4 exhibit a reduced number of vascular branch points and reduced radial expansion of the vascular plexus at P5, as shown by isolectin-B4 staining of retinal vessels
• vascular sprouting defects are due to impaired endothelial cell proliferation
• no increase in retinal vessel regression or changes in filopodia number or vessel maturation are observed
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• mice injected with tamoxifen at P1-P4 exhibit reduced endothelial cell proliferation in retinal vessels at P5, as shown by EdU staining
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cellular
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• mice injected with tamoxifen at P1-P4 exhibit reduced endothelial cell proliferation in retinal vessels at P5, as shown by EdU staining
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vision/eye
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• mice injected with tamoxifen at P1-P4 exhibit a reduced number of vascular branch points and reduced radial expansion of the vascular plexus at P5, as shown by isolectin-B4 staining of retinal vessels
• vascular sprouting defects are due to impaired endothelial cell proliferation
• no increase in retinal vessel regression or changes in filopodia number or vessel maturation are observed
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