Phenotypes associated with this allele

• Allele Symbol: Cpt1a^tm1.1Pec
• Allele Name: targeted mutation 1.1, Peter Carmeliet
• Allele ID: MGI:5749792
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cpt1a^tm1.1Pec/Cpt1a^tm1.1Pec Tg(Vil1-cre/ERT2)23Syr/0	involves: C57BL/6 * DBA/2	MGI:8159415
cn2	Cpt1a^tm1.1Pec/Cpt1a^tm1.1Pec Tg(Cdh5-cre/ERT2)1Rha/0	Not Specified	MGI:5771679

Genotype
MGI:8159415

cn1

• Allelic Composition: Cpt1a^tm1.1Pec/Cpt1a^tm1.1Pec; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased intestinal crypt stem cell number ( J:280699 )

• tamoxifen-treated mice show reduced Lgr5+ intestinal crypt stem cell numbers

• however, no effect on intestinal differentiation is observed

endocrine/exocrine glands

decreased intestinal crypt stem cell number ( J:280699 )

• tamoxifen-treated mice show reduced Lgr5+ intestinal crypt stem cell numbers

• however, no effect on intestinal differentiation is observed

homeostasis/metabolism

abnormal homeostasis ( J:280699 )

• intestinal crypts isolated from tamoxifen-treated mice show increased HMGCS2 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2) protein levels relative to controls

• however, intestinal crypt beta-hydroxybutyrate (beta-OHB) levels remain normal

Genotype
MGI:5771679

cn2

• Allelic Composition: Cpt1a^tm1.1Pec/Cpt1a^tm1.1Pec; Tg(Cdh5-cre/ERT2)1Rha/0
• Genetic Background: Not Specified

cardiovascular system

abnormal retina vasculature morphology ( J:220527 )

• mice injected with tamoxifen at P1-P4 exhibit a reduced number of vascular branch points and reduced radial expansion of the vascular plexus at P5, as shown by isolectin-B4 staining of retinal vessels

• vascular sprouting defects are due to impaired endothelial cell proliferation

• no increase in retinal vessel regression or changes in filopodia number or vessel maturation are observed

decreased vascular endothelial cell proliferation ( J:220527 )

• mice injected with tamoxifen at P1-P4 exhibit reduced endothelial cell proliferation in retinal vessels at P5, as shown by EdU staining

cellular

decreased vascular endothelial cell proliferation ( J:220527 )

• mice injected with tamoxifen at P1-P4 exhibit reduced endothelial cell proliferation in retinal vessels at P5, as shown by EdU staining

vision/eye

abnormal retina vasculature morphology ( J:220527 )

• mice injected with tamoxifen at P1-P4 exhibit a reduced number of vascular branch points and reduced radial expansion of the vascular plexus at P5, as shown by isolectin-B4 staining of retinal vessels

• vascular sprouting defects are due to impaired endothelial cell proliferation

• no increase in retinal vessel regression or changes in filopodia number or vessel maturation are observed