About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zwintem1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5749807
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zwintem1(IMPC)J/Zwintem1(IMPC)J C57BL/6NJ-Zwintem1(IMPC)J/J MGI:6263942
ht2
Zwintem1(IMPC)J/Zwint+ C57BL/6NJ-Zwintem1(IMPC)J/J MGI:6263941


Genotype
MGI:6263942
hm1
Allelic
Composition
Zwintem1(IMPC)J/Zwintem1(IMPC)J
Genetic
Background
C57BL/6NJ-Zwintem1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zwintem1(IMPC)J mutation (1 available); any Zwint mutation (21 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype

Zwintem1(IMPC)J/Zwintem1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but no embryos at E7.5. Blastocysts grown in vitro hatch from the zona pellucia but the inner cell mass/epiblast cells form a smaller outgrowth colony.

embryo
• epiblast cells form a smaller than normal outgrowth colony after 3 days in culture
• inner cell mass (ICM) cells form a smaller than normal outgrowth colony after 3 days in culture
• however, blastocysts hatch from the zona pellucida with apparent trophectoderm and primitive endoderm cells

mortality/aging
• normal looking blastocysts are present at E3.5 (36% versus expected 25%, n=11); no embryos are recovered at E7.5 with an excess number of resorption sites




Genotype
MGI:6263941
ht2
Allelic
Composition
Zwintem1(IMPC)J/Zwint+
Genetic
Background
C57BL/6NJ-Zwintem1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zwintem1(IMPC)J mutation (1 available); any Zwint mutation (21 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
IMPC - JAX





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory