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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zwintem1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5749807
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zwintem1(IMPC)J/Zwintem1(IMPC)J C57BL/6NJ-Zwintem1(IMPC)J/J MGI:6263942
ht2
Zwintem1(IMPC)J/Zwint+ C57BL/6NJ-Zwintem1(IMPC)J/J MGI:6263941


Genotype
MGI:6263942
hm1
Allelic
Composition
Zwintem1(IMPC)J/Zwintem1(IMPC)J
Genetic
Background
C57BL/6NJ-Zwintem1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zwintem1(IMPC)J mutation (1 available); any Zwint mutation (21 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype

Zwintem1(IMPC)J/Zwintem1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but no embryos at E7.5. Blastocysts grown in vitro hatch from the zona pellucia but the inner cell mass/epiblast cells form a smaller outgrowth colony.

embryo
• epiblast cells form a smaller than normal outgrowth colony after 3 days in culture
• inner cell mass (ICM) cells form a smaller than normal outgrowth colony after 3 days in culture
• however, blastocysts hatch from the zona pellucida with apparent trophectoderm and primitive endoderm cells

mortality/aging
• normal looking blastocysts are present at E3.5 (36% versus expected 25%, n=11); no embryos are recovered at E7.5 with an excess number of resorption sites




Genotype
MGI:6263941
ht2
Allelic
Composition
Zwintem1(IMPC)J/Zwint+
Genetic
Background
C57BL/6NJ-Zwintem1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zwintem1(IMPC)J mutation (1 available); any Zwint mutation (21 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
IMPC - JAX





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory