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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ndufs8em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5749812
Summary 2 genotypes


Genotype
MGI:6262991
hm1
Allelic
Composition		 Ndufs8em1(IMPC)J/Ndufs8em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Ndufs8em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufs8em1(IMPC)J mutation (1 available); any Ndufs8 mutation (16 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7736154
hm2
Allelic
Composition		 Ndufs8em1(IMPC)J/Ndufs8em1(IMPC)J
Genetic
Background		 C57BL/6N-Ndufs8em1(IMPC)J/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufs8em1(IMPC)J mutation (1 available); any Ndufs8 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ndufs8em1(IMPC)J/Ndufs8em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

embryo
failure to gastrulate ( J:290315 , J:279207 )
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)
embryonic growth arrest ( J:279207 )
• embryos arrest prior to gastrulation
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
abnormal egg cylinder morphology ( J:279207 )
• a rudimentary egg cylinder is observed at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no embryonic node is present at E7.5
failure of primitive streak formation ( J:279207 )
• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory