Phenotypes associated with this allele

• Allele Symbol: Kcnk13^em1(IMPC)H
• Allele Name: endonuclease-mediated mutation 1, Harwell
• Allele ID: MGI:5749943
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnk13^em1(IMPC)H/Kcnk13^em1(IMPC)H	C57BL/6N-Kcnk13^em1(IMPC)H/H	MGI:6262739
hm2	Kcnk13^em1(IMPC)H/Kcnk13^em1(IMPC)H	involves: C57BL/6NTac	MGI:6158525

Genotype
MGI:6262739

hm1

• Allelic Composition: Kcnk13^em1(IMPC)H/Kcnk13^em1(IMPC)H
• Genetic Background: C57BL/6N-Kcnk13^em1(IMPC)H/H

Data Sources

IMPC Data for Kcnk13

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased basophil cell number ( J:211773 )

IMPC - HAR

increased mean corpuscular volume ( J:211773 )

♂

IMPC - HAR

increased red blood cell distribution width ( J:211773 )

♂

IMPC - HAR

increased monocyte cell number ( J:211773 )

IMPC - HAR

immune system

increased basophil cell number ( J:211773 )

IMPC - HAR

increased monocyte cell number ( J:211773 )

IMPC - HAR

Genotype
MGI:6158525

hm2

• Allelic Composition: Kcnk13^em1(IMPC)H/Kcnk13^em1(IMPC)H
• Genetic Background: involves: C57BL/6NTac

nervous system

abnormal microglial cell morphology ( J:256020 )

• much less complex ramification pattern, both in brain slices and in vivo brain

• significantly decreased number of processes, smaller total process length, and fewer process intersections with shells at different radii from the cell soma

• no change in tiling pattern or mean microglial density in tissue

abnormal microglial cell physiology ( J:256020 )

• initial rate of surveillance reduced (41% in brain slices and 45% in brain in vivo) and cumulative area (in maximum intensity projections) surveyed after an hour reduced (31% and 38%)

immune system

abnormal microglial cell morphology ( J:256020 )

• much less complex ramification pattern, both in brain slices and in vivo brain

• significantly decreased number of processes, smaller total process length, and fewer process intersections with shells at different radii from the cell soma

• no change in tiling pattern or mean microglial density in tissue

abnormal microglial cell physiology ( J:256020 )

• initial rate of surveillance reduced (41% in brain slices and 45% in brain in vivo) and cumulative area (in maximum intensity projections) surveyed after an hour reduced (31% and 38%)

hematopoietic system

abnormal microglial cell morphology ( J:256020 )

• much less complex ramification pattern, both in brain slices and in vivo brain

• significantly decreased number of processes, smaller total process length, and fewer process intersections with shells at different radii from the cell soma

• no change in tiling pattern or mean microglial density in tissue

abnormal microglial cell physiology ( J:256020 )

• initial rate of surveillance reduced (41% in brain slices and 45% in brain in vivo) and cumulative area (in maximum intensity projections) surveyed after an hour reduced (31% and 38%)