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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fnip2tm1.1Lss
targeted mutation 1.1, Laura S Schmidt
MGI:5749952
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fnip2tm1.1Lss/Fnip2tm1.1Lss
Tg(Cdh16-cre)91Igr/0 		involves: C57BL/6 * ICR MGI:5897111
cn2
 		Fnip1tm1.1Baba/Fnip1tm1.1Baba
Fnip2tm1.1Lss/Fnip2tm1.1Lss
Tg(Cdh16-cre)91Igr/0 		involves: C57BL/6 * ICR MGI:5897114
cn3
 		Flcntm1Baba/Flcntm1Baba
Fnip1tm1.1Baba/Fnip1tm1.1Baba
Fnip2tm1.1Lss/Fnip2tm1.1Lss
Tg(Cdh16-cre)91Igr/0 		involves: C57BL/6 * ICR MGI:5897115


Genotype
MGI:5897111
cn1
Allelic
Composition		 Fnip2tm1.1Lss/Fnip2tm1.1Lss
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip2tm1.1Lss mutation (0 available); any Fnip2 mutation (60 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:220672 )
N
• no kidney phenotypes detected




Genotype
MGI:5897114
cn2
Allelic
Composition		 Fnip1tm1.1Baba/Fnip1tm1.1Baba
Fnip2tm1.1Lss/Fnip2tm1.1Lss
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.1Baba mutation (0 available); any Fnip1 mutation (60 available)
Fnip2tm1.1Lss mutation (0 available); any Fnip2 mutation (60 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:220672 )
• survival time is about 3 weeks

renal/urinary system

cellular
abnormal mitochondrial physiology ( J:220672 )
• increased respiratory capacity and mitochondrial surface area indicating increased mitochondrial biogenesis

growth/size/body
polycystic kidney ( J:220672 )
enlarged kidney ( J:220672 )




Genotype
MGI:5897115
cn3
Allelic
Composition		 Flcntm1Baba/Flcntm1Baba
Fnip1tm1.1Baba/Fnip1tm1.1Baba
Fnip2tm1.1Lss/Fnip2tm1.1Lss
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flcntm1Baba mutation (0 available); any Flcn mutation (42 available)
Fnip1tm1.1Baba mutation (0 available); any Fnip1 mutation (60 available)
Fnip2tm1.1Lss mutation (0 available); any Fnip2 mutation (60 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
polycystic kidney ( J:220672 )
• no increase in severity of cystic phenotype compared to mutant mice wild-type for Flcn
enlarged kidney ( J:220672 )
• no increase in severity of phenotype compared to mutant mice wild-type for Flcn

growth/size/body
polycystic kidney ( J:220672 )
• no increase in severity of cystic phenotype compared to mutant mice wild-type for Flcn
enlarged kidney ( J:220672 )
• no increase in severity of phenotype compared to mutant mice wild-type for Flcn




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory