Phenotypes associated with this allele

• Allele Symbol: Npr1^tm1.1Kkan
• Allele Name: targeted mutation 1.1, Kenji Kangawa
• Allele ID: MGI:5750455
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Npr1^tm1.1Kkan/Npr1^tm1.1Kkan Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL	MGI:5792676

Genotype
MGI:5792676

cn1

• Allelic Composition: Npr1^tm1.1Kkan/Npr1^tm1.1Kkan; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Npr1^tm1.1Kkan/Npr1^tm1.1Kkan Tg(Tek-cre)1Ywa/0 mice injected with B16/F10 cells show increased number of plumonary and cardiac metastases

cardiovascular system

cardiac hypertrophy ( J:220676 )

• mice exhibit cardiac hypertrophy relative to Npr1^tm1.1Kkan homozygotes

increased systemic arterial blood pressure ( J:220676 )

• mice exhibit a significant increase in blood pressure relative to Npr1^tm1.1Kkan homozygotes

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:220676 )

• after injection of B16/F10 melanoma cells, mice exhibit a significant reduction in overall survival relative to similarly treated Npr1^tm1.1Kkan homozygotes

neoplasm

increased metastatic potential ( J:220676 )

• at 2 weeks after injection of B16/F10 melanoma cells, mice show a significantly higher number of pulmonary metastases (nodules) than Npr1^tm1.1Kkan homozygotes

• in addition, one-third of mice exhibit cardiac metastases, whereas no cardiac metastasis is found in Npr1^tm1.1Kkan homozygotes

growth/size/body

cardiac hypertrophy ( J:220676 )

• mice exhibit cardiac hypertrophy relative to Npr1^tm1.1Kkan homozygotes