digestive/alimentary system
• 100% of mice develop rectal prolapse by approximately 75 days
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• increase in levels of fecal bacteria as compared to Il10 mutation alone
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• severe uniform colitis in 100% of mice; presence of intestinal endothelial cell (IEC)-specific Tlr5 null mutation exacerbates phenotype
• increased incidence of rectal prolapse; presence of IEC-specific Tlr5 null mutation exacerbates phenotype
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immune system
• severe uniform colitis in 100% of mice; presence of intestinal endothelial cell (IEC)-specific Tlr5 null mutation exacerbates phenotype
• increased incidence of rectal prolapse; presence of IEC-specific Tlr5 null mutation exacerbates phenotype
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mortality/aging
• mice are euthanized due to rectal prolapse
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