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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tlr5tm1.1Gewr
targeted mutation 1.1, Andrew Gewirtz
MGI:5750875
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Il10tm1Cgn/Il10tm1Cgn
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL MGI:5751560
cn2
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Tg(Itgax-cre,-EGFP)4097Ach/?
involves: C57BL/6J * C57BL/6NTac MGI:5751549
cn3
Tg(Vil1-cre)997Gum/?
Tlr4lps-del/Tlr4lps-del
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL MGI:5751557
cn4
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: C57BL/6J * C57BL/6NTac * SJL/J MGI:5751550
cx5
Il10tm1Cgn/Il10tm1Cgn
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac MGI:5751562


Genotype
MGI:5751560
cn1
Allelic
Composition
Il10tm1Cgn/Il10tm1Cgn
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation (15 available); any Il10 mutation (45 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• 100% of mice develop rectal prolapse by approximately 75 days
• increase in levels of fecal bacteria as compared to Il10 mutation alone
• severe uniform colitis in 100% of mice; presence of intestinal endothelial cell (IEC)-specific Tlr5 null mutation exacerbates phenotype
• increased incidence of rectal prolapse; presence of IEC-specific Tlr5 null mutation exacerbates phenotype

immune system
• severe uniform colitis in 100% of mice; presence of intestinal endothelial cell (IEC)-specific Tlr5 null mutation exacerbates phenotype
• increased incidence of rectal prolapse; presence of IEC-specific Tlr5 null mutation exacerbates phenotype

mortality/aging
• mice are euthanized due to rectal prolapse




Genotype
MGI:5751549
cn2
Allelic
Composition
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic
Background
involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue

digestive/alimentary system
• delayed clearance of pathobiont bacteria
• decreased distance of fecal bacteria from intestinal epithelial cells

immune system
N
• mice do not exhibit spontaneous colitis, low grade inflammation or metabolic syndrome




Genotype
MGI:5751557
cn3
Allelic
Composition
Tg(Vil1-cre)997Gum/?
Tlr4lps-del/Tlr4lps-del
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic
Background
involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr4lps-del mutation (6 available); any Tlr4 mutation (91 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice do not exhibit symptoms of metabolic syndrome
• fat pad weight, body weight, spleen weight, colon weight, and fasting glucose levels are similar to wild-type

behavior/neurological

digestive/alimentary system
• increased colon weight
• low grade inflammation, however, phenotype is less severe than in mice with wild-type Tlr4

immune system
• low grade inflammation, however, phenotype is less severe than in mice with wild-type Tlr4




Genotype
MGI:5751550
cn4
Allelic
Composition
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic
Background
involves: C57BL/6J * C57BL/6NTac * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• increased adiposity on chow and high fat diet

behavior/neurological

digestive/alimentary system
• shorter and heavier colons on chow diet
• increased colon weight on high fat diet, length is similar to wild-type
• increase in levels of fecal bacteria
• increase in levels of bacteria adherent to the colonic mucosa
• decreased distance of bacteria from intestinal epithelial cells
• delayed clearance of pathobiont bacteria
• alteration in microbiota composition as compared to controls
• low grade inflammation, however mice do not develop spontaneous colitis
• increased mortality observed in mice on low dose DSS

growth/size/body
• on chow and high fat diet
• mild splenomegaly on chow and high fat diet

hematopoietic system
• mild splenomegaly on chow and high fat diet

homeostasis/metabolism
• increased levels of blood glucose in males following 15 hr fast
• high fat diet compounds hyperglycemia especially in female mice

immune system
• low grade inflammation, however mice do not develop spontaneous colitis
• increased mortality observed in mice on low dose DSS
• mild splenomegaly on chow and high fat diet
• increased levels of colonic IL1B secretion in males treated with DSS

mortality/aging
• increased mortality observed in mice on low dose DSS




Genotype
MGI:5751562
cx5
Allelic
Composition
Il10tm1Cgn/Il10tm1Cgn
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation (15 available); any Il10 mutation (45 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• most mice develop rectal prolapse by 150 days
• severe colitis in 100% of mice; phenotype is less severe than in the presence of the intestinal endothelial cell (IEC)-specific Tlr5 null mutation

immune system
• severe colitis in 100% of mice; phenotype is less severe than in the presence of the intestinal endothelial cell (IEC)-specific Tlr5 null mutation

mortality/aging
• mice are euthanized by 5 months due to rectal prolapse





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory