About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tlr5tm1.1Gewr
targeted mutation 1.1, Andrew Gewirtz
MGI:5750875
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Il10tm1Cgn/Il10tm1Cgn
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL MGI:5751560
cn2
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Tg(Itgax-cre,-EGFP)4097Ach/?
involves: C57BL/6J * C57BL/6NTac MGI:5751549
cn3
Tg(Vil1-cre)997Gum/?
Tlr4lps-del/Tlr4lps-del
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL MGI:5751557
cn4
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: C57BL/6J * C57BL/6NTac * SJL/J MGI:5751550
cx5
Il10tm1Cgn/Il10tm1Cgn
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac MGI:5751562


Genotype
MGI:5751560
cn1
Allelic
Composition
Il10tm1Cgn/Il10tm1Cgn
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation (15 available); any Il10 mutation (45 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• 100% of mice develop rectal prolapse by approximately 75 days
• increase in levels of fecal bacteria as compared to Il10 mutation alone
• severe uniform colitis in 100% of mice; presence of intestinal endothelial cell (IEC)-specific Tlr5 null mutation exacerbates phenotype
• increased incidence of rectal prolapse; presence of IEC-specific Tlr5 null mutation exacerbates phenotype

immune system
• severe uniform colitis in 100% of mice; presence of intestinal endothelial cell (IEC)-specific Tlr5 null mutation exacerbates phenotype
• increased incidence of rectal prolapse; presence of IEC-specific Tlr5 null mutation exacerbates phenotype

mortality/aging
• mice are euthanized due to rectal prolapse




Genotype
MGI:5751549
cn2
Allelic
Composition
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic
Background
involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue

digestive/alimentary system
• delayed clearance of pathobiont bacteria
• decreased distance of fecal bacteria from intestinal epithelial cells

immune system
N
• mice do not exhibit spontaneous colitis, low grade inflammation or metabolic syndrome




Genotype
MGI:5751557
cn3
Allelic
Composition
Tg(Vil1-cre)997Gum/?
Tlr4lps-del/Tlr4lps-del
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic
Background
involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr4lps-del mutation (6 available); any Tlr4 mutation (91 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice do not exhibit symptoms of metabolic syndrome
• fat pad weight, body weight, spleen weight, colon weight, and fasting glucose levels are similar to wild-type

behavior/neurological

digestive/alimentary system
• increased colon weight
• low grade inflammation, however, phenotype is less severe than in mice with wild-type Tlr4

immune system
• low grade inflammation, however, phenotype is less severe than in mice with wild-type Tlr4




Genotype
MGI:5751550
cn4
Allelic
Composition
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic
Background
involves: C57BL/6J * C57BL/6NTac * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• increased adiposity on chow and high fat diet

behavior/neurological

digestive/alimentary system
• shorter and heavier colons on chow diet
• increased colon weight on high fat diet, length is similar to wild-type
• increase in levels of fecal bacteria
• increase in levels of bacteria adherent to the colonic mucosa
• decreased distance of bacteria from intestinal epithelial cells
• delayed clearance of pathobiont bacteria
• alteration in microbiota composition as compared to controls
• low grade inflammation, however mice do not develop spontaneous colitis
• increased mortality observed in mice on low dose DSS

growth/size/body
• on chow and high fat diet
• mild splenomegaly on chow and high fat diet

hematopoietic system
• mild splenomegaly on chow and high fat diet

homeostasis/metabolism
• increased levels of blood glucose in males following 15 hr fast
• high fat diet compounds hyperglycemia especially in female mice

immune system
• low grade inflammation, however mice do not develop spontaneous colitis
• increased mortality observed in mice on low dose DSS
• mild splenomegaly on chow and high fat diet
• increased levels of colonic IL1B secretion in males treated with DSS

mortality/aging
• increased mortality observed in mice on low dose DSS




Genotype
MGI:5751562
cx5
Allelic
Composition
Il10tm1Cgn/Il10tm1Cgn
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation (15 available); any Il10 mutation (45 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• most mice develop rectal prolapse by 150 days
• severe colitis in 100% of mice; phenotype is less severe than in the presence of the intestinal endothelial cell (IEC)-specific Tlr5 null mutation

immune system
• severe colitis in 100% of mice; phenotype is less severe than in the presence of the intestinal endothelial cell (IEC)-specific Tlr5 null mutation

mortality/aging
• mice are euthanized by 5 months due to rectal prolapse





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory