Analysis Tools|
Allele Symbol Allele Name Allele ID |
Lmnatm4Stw targeted mutation 4, Colin L Stewart MGI:5750954 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are born at normal Mendelian ratios and survive for >1 year with no gross defects, such as shortened lifespan or reduced weight
• H&E staining showed normal gastrointestinal (GI) tract histology (duodenum, jejunum, ileum and colon) at 10 weeks of age
• Ki67 staining revealed normal GI epithelial proliferation at 1 year of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 16-32 weeks of age, mice show a 1.5-fold increase in the frequency of larger polyps (2-5 mm) in the duodenum relative to ApcMin heterozygous controls
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• mice show a 3-fold increase in the frequency of larger polyps (2-5 mm) in the proximal jejunum relative to ApcMin heterozygous controls
• however, the total number of polyps found in the gastrointestinal tract (duodenum, proximal and distal jejunum, ileum and colon) is not significantly altered relative to ApcMin heterozygous controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are born at normal Mendelian ratios but survive only to P12-P18
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• by P14, mice of both sexes are significantly smaller than wild-type or heterozygous controls
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• by P12-P14, body weight is ~50% that of wild-type or heterozygous controls
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• mice exhibit retarded growth from P10 onwards
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• mice display a stiff walking posture
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• significantly smaller diameter myofibrils in quadriceps muscles
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• increased incidence of centrally located nuclei in quadriceps muscles
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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