Phenotypes associated with this allele

• Allele Symbol: Mir193b^tm1.2Mam
• Allele Name: targeted mutation 1.2, Lothar Hennighausen
• Allele ID: MGI:5750969
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir193b^tm1.2Mam/Mir193b^tm1.2Mam	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5750971

Genotype
MGI:5750971

hm1

• Allelic Composition: Mir193b^tm1.2Mam/Mir193b^tm1.2Mam
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

premature mammary gland growth during pregnancy ( J:216615 )

♀ • precocious alveolar differentiation

abnormal mammary gland epithelium morphology ( J:216615 )

♀ • mammary epithelium exhibit precocious alveolar differentiation during puberty and pregnancy

abnormal mammary gland epithelium physiology ( J:216615 )

♀ • in culture, mammary epithelial cells from nulliparous 8 to 12 weeks old mice exhibit reduced capacity to form colonies but form larger colonies compared with wild-type cells

♀ • transplanted mammary epithelial cells exhibit increased formation of ductal tree compared with wild-type cells

reproductive system

premature mammary gland growth during pregnancy ( J:216615 )

♀ • precocious alveolar differentiation

integument

premature mammary gland growth during pregnancy ( J:216615 )

♀ • precocious alveolar differentiation

abnormal mammary gland epithelium morphology ( J:216615 )

♀ • mammary epithelium exhibit precocious alveolar differentiation during puberty and pregnancy

abnormal mammary gland epithelium physiology ( J:216615 )

♀ • in culture, mammary epithelial cells from nulliparous 8 to 12 weeks old mice exhibit reduced capacity to form colonies but form larger colonies compared with wild-type cells

♀ • transplanted mammary epithelial cells exhibit increased formation of ductal tree compared with wild-type cells