Phenotypes associated with this allele

• Allele Symbol: Klrc1^tm1Mmka
• Allele Name: targeted mutation 1, Mitsuo Matsuoka
• Allele ID: MGI:5751068
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klrc1^tm1Mmka/Klrc1^tm1Mmka	B6.129-Klrc1^tm1Mmka	MGI:5751093

Genotype
MGI:5751093

hm1

• Allelic Composition: Klrc1^tm1Mmka/Klrc1^tm1Mmka
• Genetic Background: B6.129-Klrc1^tm1Mmka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:222503 )

N • in re-stimulated influenza specific CD8+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:222503 )

• following intranasal influenza infection

increased interferon-gamma secretion ( J:222503 )

• in re-stimulated influenza specific CD8+ T cells

increased interleukin-2 secretion ( J:222503 )

• in re-stimulated influenza specific CD8+ T cells

decreased tumor necrosis factor secretion ( J:222503 )

• in bronchoalveolar lavage following intranasal influenza infection

increased tumor necrosis factor secretion ( J:222503 )

• in re-stimulated influenza specific CD8+ T cells

liver inflammation ( J:222503 )

• in adenovirus-infected mice

lung inflammation ( J:222503 )

• following intranasal influenza infection

increased susceptibility to Adenoviridae infection ( J:222503 )

• adenovirus-infected mice exhibit increased liver damage with increased serum alanine transaminase levels, increased lymphocytic infiltrate in the liver and increased liver CD8+ T cells compared with wild-type mice

increased susceptibility to Orthomyxoviridae infection ( J:222503 )

• following intranasal influenza infection, mice exhibit decreased CD8+ T cell frequency and TNFalpha in bronchoalveolar lavage and increased lung inflammation compared with wild-type mice

• however, influenza-infected mice exhibit normal CD4 T+ and NP366-specific T cell frequencies

homeostasis/metabolism

increased circulating alanine transaminase level ( J:222503 )

• in adenovirus-infected mice

liver/biliary system

liver inflammation ( J:222503 )

• in adenovirus-infected mice

respiratory system

lung inflammation ( J:222503 )

• following intranasal influenza infection

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:222503 )

• following intranasal influenza infection