Phenotypes associated with this allele

• Allele Symbol: Cry2^tm1.1Yf
• Allele Name: targeted mutation 1.1, Yoshitaka Fukada
• Allele ID: MGI:5751243
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cry2^tm1.1Yf/Cry2^tm1.1Yf	B6J.Cg-Cry2^tm1.1Yf	MGI:5781225
cx2	Cry2^tm1.1Yf/Cry2^tm1.1Yf Per2^tm1Jt/Per2^tm1Jt	B6J.Cg-Cry2^tm1.1Yf Per2^tm1Jt	MGI:5781227

Genotype
MGI:5781225

hm1

• Allelic Composition: Cry2^tm1.1Yf/Cry2^tm1.1Yf
• Genetic Background: B6J.Cg-Cry2^tm1.1Yf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

prolonged circadian behavior period ( J:224319 )

• when released into constant darkness (DD), mice display a significantly longer free-running period of the wheel-running activity rhythm than wild-type controls

• however, mice show a similar phase delay or advance of the activity rhythms when exposed to a 30-min light pulse at circadian time 14 (CT14) or CT22, respectively, with no significant alterations in phase shifts relative to wild-type controls

Genotype
MGI:5781227

cx2

• Allelic Composition: Cry2^tm1.1Yf/Cry2^tm1.1Yf; Per2^tm1Jt/Per2^tm1Jt
• Genetic Background: B6J.Cg-Cry2^tm1.1Yf Per2^tm1Jt

liver/biliary system

abnormal liver physiology ( J:224319 )

• bioluminescence rhythms recorded from cultured liver slices revealed a significantly lengthened circadian period of the liver peripheral clock relative to wild-type controls