All Phenotypes Vps25<m1Lis> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vps25^m1Lis/Vps25^m1Lis	involves: C3H * C57BL/6J	MGI:5751501
ht2	Vps25^m1Lis/Vps25^{tm1(KOMP)Vlcg}	involves: C3H * C57BL/6J * C57BL/6NTac	MGI:5751504
cx3	Shh^tm1Chg/Shh⁺ Vps25^m1Lis/Vps25^m1Lis	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J	MGI:5751502

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:223082 )

• mice survive until E15.5 to E16.5

limbs/digits/tail

polydactyly ( J:223082 )

• fully penetrant in the hindlimb

• less severe and not fully penetrant in forelimbs

preaxial polydactyly ( J:223082 )

• at E14.5

abnormal hindlimb zeugopod morphology ( J:223082 )

• short and thick at E14.5

short limbs ( J:223082 )

skeleton

mandible hypoplasia ( J:223082 )

abnormal scapula morphology ( J:223082 )

• thin

scapular bone foramen ( J:223082 )

cellular

abnormal cell morphology ( J:223082 )

• mouse embryonic fibroblasts, limb bud apical ectodermal ridge cells and mesenchyme exhibit enlarged multi-vesicular bodies (a form of late endosome) compared with wild-type cells

increased apoptosis ( J:223082 )

• in the hindlimb anterior apical ectodermal ridge, less pronounced in forelimbs

increased cell proliferation ( J:223082 )

• in the hindlimb anterior apical ectodermal ridge, less pronounced in forelimbs

craniofacial

mandible hypoplasia ( J:223082 )

short snout ( J:223082 )

• stunted

abnormal outer ear morphology ( J:223082 )

growth/size/body

short snout ( J:223082 )

• stunted

abnormal outer ear morphology ( J:223082 )

hearing/vestibular/ear

abnormal outer ear morphology ( J:223082 )

Allelic Composition	Vps25^m1Lis/Vps25^{tm1(KOMP)Vlcg}
Genetic Background	involves: C3H * C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vps25^m1Lis mutation (0 available); any Vps25 mutation (15 available)
Vps25^{tm1(KOMP)Vlcg} mutation (2 available); any Vps25 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

fetal growth retardation ( J:223082 )

• as early as E9.5

cardiovascular system

hemorrhage ( J:223082 )

• as early as E9.5

Allelic Composition	Shh^tm1Chg/Shh⁺ Vps25^m1Lis/Vps25^m1Lis
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)
Vps25^m1Lis mutation (0 available); any Vps25 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

mandible hypoplasia ( J:223082 )